中国医学创新Issue(26)：18-19,2.DOI:10.3969/j.issn.1674-4985.2013.26.008
HBV基因型与恩替卡韦治疗的病毒学应答
HBV Genotypes and Virologic Response in Patients with Entecavir Treatment
蔡乐斌1
作者信息
- 1. 广州市南沙中心医院 广东 广州 511457
- 折叠
摘要
Abstract
Objective:To study the association between HBV genotype and the virologic response in patients with entecavir treatment. Method:The HBV genotypes of 56 patients with chronic hepatitis B(CHB)were detected by INNO-LiPA assay.All the patients were given entecavir (0.5 mg/d)treatment for 48 weeks.The changes of ALT level,HBeAg status and serum HBV DNA level were observed before and after treatment in all patients.Result:Among 56 CHB cases,30 cases were genotype B,26 were genotype C.There were no significant differences in the changes of ALT normalization,HBeAg seroconversion and serum HBV DNA levels between the patients infected HBV genotype B or C(P>0.05). Conclusion:The study shows that the virologic response to entecavir treatment is not correlated with HBV genotype.关键词
慢性乙型肝炎/恩替卡韦/HBV基因型/HBV DNAKey words
Hepatitis B virus/Entecavir/Genotype/HBV DNA引用本文复制引用
蔡乐斌..HBV基因型与恩替卡韦治疗的病毒学应答[J].中国医学创新,2013,(26):18-19,2.
