摘要
Abstract
Objective:To explore the change of bone mineral density(BMD),bone metabolism biochemical markers and related cytokines in patients with COPD in aged men.Method:55 cases of elderly male COPD patients as the COPD group were selected,and 50 age-matched healthy subjects as the control group.The bone mineral density(BMD)of lumbar vertebrae and proximal end of the femur were measured by dual energy X-ray absorptiometry.Serum BGP and BALP were used as markers for bone formation.β-CTx and NTX were measured as the bone absorption markers.Cytokines IL-6 and TNF-αwere measured.Result:In the COPD group,the BMD of lumbar vertebrae and proximal end of the femur were significantly lower,there was significant difference(P<0.05).Bone formation markers osteocalcin of COPD group compared with the control group did not significantly decrease, whereasβ-CTx was slightly higher than that of control group,the difference had no statistical significance(P>0.05).The level of BALP in COPD group was significantly lower than the control group,while NTX was higher than that of the control group,the differences were statistically significant(P<0.05). The TNF-αof the COPD group was significantly higher than that of the control group,the difference was statistically significant(P<0.05),while IL-6 was slightly higher than that of the control group,no significant difference(P>0.05).Conclusion:The level of BMD in elderly male patients with COPD is significantly lower than that in healthy people with same age,and more susceptible to osteoporosis.In COPD group the osteoclastic factors such as IL-6 and TNF-αincreases.Bone resorption increases,which promotes the occurrence of osteoporosis.关键词
慢性阻塞性肺疾病/骨质疏松症/骨密度/细胞因子Key words
Chronic obstructive pulmonary diseases/Osteoporosis/Bone mineral density/Cytokine
