中国医学创新Issue(27)：28-29,2.DOI:10.3969/j.issn.1674-4985.2013.27.013
来氟米特在治疗伴外周关节炎的强直性脊柱炎中的作用分析
The Effect Analysis of Leflunomide in the Treatment of Ankylosing Spondylitis with Peripheral Arthritis
邱敏丽 1潘云峰 1方霖楷 1古洁若1
作者信息
- 1. 中山大学附属第三医院 广东 广州 510630
- 折叠
摘要
Abstract
Objective:To observe the efficacy and safety of leflunomide(LEF)in the treatment of Ankylosing Spondylitis(AS)with peripheral arthritis. Method:150 patients with active AS with peripheral arthritis were randomized at baseline to receive LEF or SASP or placebo for 24 weeks. The curative effect and the incidence of adverse reactions among the three groups were compared. Result:LEF could significantly reduce the BASDAI index and the tender and swelling peripheral joints counts of AS. And the rate of ASAS20 improvement was significantly elevated. The efficacy of the LEF group was not different compared with the SASP group,but the adverse reactions incidence of LEF was significantly lower than SASP,not different from the placebo. Conclusion:Using LEF in the treatment of AS with peripheral arthritis has shown that it is effective and safe.关键词
来氟米特/强直性脊柱炎/疗效/不良反应Key words
Leflunomide/Ankylosing Spondylitis/Curative effect/Adverse reaction引用本文复制引用
邱敏丽,潘云峰,方霖楷,古洁若..来氟米特在治疗伴外周关节炎的强直性脊柱炎中的作用分析[J].中国医学创新,2013,(27):28-29,2.
