摘要
Abstract
Objective:To investigate the dispersion of HBV in the human body and discuss whether it is related to the infection in clinical phenotype.Method:A sequencing of PCR was conducted after the amplification of PCR,then the HBV genotype of 300 HBV patients was analyzed and t and χ2 test methods were applied to analyze the relationship between the genotype and clinical phenotype of HBV.Result:Among the 300 HBV patients,patients with B genotype had 180 patients,accounted for about 60%;those with C genotype had 120 patients,accounted for 40%.Patients with B genotype(29.5±9.8)years old was obviously younger than those with C genotype(35.2±11.4)years old,the difference was statistically significant (P<0.05);there’s no statistical significance in the difference of HBV genotype dispersion caused by gender difference(P>0.05).C genotype was 31.2%in chronic asymptomatic HBV carriers proportion,in patients with chronic hepatitis B was 30.2%,significantly lower than the 58.6%patients with hepatocellular carcinoma and the 60%patients with liver cirrhosis,the differences were statistically significant(P<0.05);the positive rate of B genotype and HBeAg(55.6%)was obviously lower than that of C genotype(71.7%),the difference was statistically significant(P<0.05);the HBV-DNA content logo value of the serum of patients with B genotype(5.62±0.92)was apparently lower than that of patients with C genotype(5.98±0.76),the difference was statistically significant(P<0.05).Conclusion:Physical condition of clinical patients has an inseparable relationship with HBV genotype. When it comes to the age,HBeAg positive ratio and virus level of the patients,those of the patients with C genotype are obviously more than those of patients with B genotype,thus,conditions of patients with C genotype will probably turn into cirrhosis or even liver cancer.关键词
乙型肝炎病毒/临床表型/基因型Key words
Hepatitis b Virus/Clinical phenotype/Genotype
