中国医药科学Issue(15)：19-20,42,3.
格列美脲单用或联合二甲双胍控制不佳的2型糖尿病患者加用西格列汀的疗效观察
Efficacy of sitagliptin in patients with type 2 diabetes mellitus inadequately controlled on glimepiride alone or on glimepiride and metformin
许琪 1郑雪瑛 1陈慎仁1
作者信息
- 1. 汕头大学医学院第二附属医院内分泌科,广东汕头,515041
- 折叠
摘要
Abstract
Objective To evaluate the efficacy and safety of a treatment with sitagliptin in patients with type 2 diabetes who had inadequate glycemic control while on glimepiride alone or in combination with metformin. Methods Of these 40 patients,20 were on glimepiride monotherapy and 20 were on glimepiride plus metformin combination therapy. All patients were provided sitagliptin therapy for 16 weeks. Results After 16 weeks,HbA1C,FPG and 2 h PG were significantly reduced(P<0.01),while FIns and homeostasis model assessment-βwere significantly increased (P<0.05)by the addition of sitagliptin. Low incidence of hypoglycemia and less gastrointestinal adverse reactions were found in the addition of sitagliptin. Conclusion Sitagliptin 100 mg once daily may be able to significantly improve glycemic control and β-cell function in patients with type 2 diabetes who have inadequate glycemic control with glimepiride or glimepiride plus metformin therapy. The addition of sitagliptin is generally well tolerated.关键词
2型糖尿病/格列美脲/二甲双胍/西格列汀Key words
Type 2 diabetes mellitus/Glimepiride/Metformin/Sitagliptin分类
医药卫生引用本文复制引用
许琪,郑雪瑛,陈慎仁..格列美脲单用或联合二甲双胍控制不佳的2型糖尿病患者加用西格列汀的疗效观察[J].中国医药科学,2013,(15):19-20,42,3.
