针灸临床杂志Issue(8)：47-50,4.
穴位埋线对慢性萎缩性胃炎大鼠 Toll样受体4和核因子-κB表达的影响
Effect of Catgut Embedding on the Expression of Toll-like Receptor 4 and Nuclear Factor-κB in Chronic Atrophic Gastritis in Rats
摘要
Abstract
Objective:To investigate the catgut embedding chronic atrophic gastritis ( CAG ) model of gastric mucosa Toll-like receptor 4(TLR4) and nuclear factor-kappa B(NF-κB) expression and its possible mech-anism .Methods:60 SD rats were randomly divided into four groups , normal control group , model group , natu-ral recovery group , embedding group , with 15 rats in each group .Except the normal control group , other groups were used the free drinking rats 100 mg/L methyl-nitro-nitrosoguanidine ( MNNG) with the hungry eat disor-ders law CAG model .Normal control group , model group after 12 weeks of successful modeling were sacrificed , natural recovery group after 12 weeks of modeling was with no treatment , embedding select group after 12 weeks of modeling had catgut embedding treatment at Zhongwan ,Weiyu, Zusanli,one treatment a week for 8 weeks. Observe mucosal histopathological and ultrastructural changes after the end of treatment , immunohistochemical detection of TLR4 and NF-κB expression .Results:①Compared with the normal control group , TLR4, NF-κB protein expression in gastric mucosa increased significantly ( P<0.01);②Compared with model group , in gastric mucosa of TLR4 and NF-κB protein expression natural recovery group were no significant difference ( P>0 .05 );③Compared with model group , TLR4 and NF-κB protein expression in catgut embedding group decreased significantly ( P<0.05 or P<0.01 );④Compared with natural recovery group ,TLR4 and NF-κB protein expression in catgut embedding group decreased ( P<0.05);⑤light microscopy and electron microsco-py between groups were with a significant difference .Conclusion:Catgut embedding can decrease TLR 4 and NF-κB expression, meliorate gastric mucosa injury, and can play a gastric mucosal protective effect by inhibi-ting the inflammatory response .关键词
慢性萎缩性胃炎/Toll样受体4/核因子-κB/穴位埋线/疾病模型/动物/大鼠Key words
Chronic atrophic gastritis/Toll-like receptor 4/Nuclear factor -κB/Catgut embedding/Disease model/Animals/Rats分类
医药卫生引用本文复制引用
陈璐,李素荷,钟国新,樊永磊,张璇,黄志毅..穴位埋线对慢性萎缩性胃炎大鼠 Toll样受体4和核因子-κB表达的影响[J].针灸临床杂志,2013,(8):47-50,4.基金项目
国家自然科学基金项目，编号81072876。 （）
