浙江医学Issue(16)：1498-1501,4.
化痰行瘀汤对肝纤维化大鼠组织病理学及羟脯氨酸含量的影响
陈国中 1徐珊 2张永生 2朱飞叶2
作者信息
- 1. 浙江省立同德医院中医内科, 杭州,310012
- 2. 浙江中医药大学基础医学院
- 折叠
摘要
Abstract
Objective To assess the therapeutic effects of Huatan Xingyu (HTXY) decoction on experimental hepatic fi-brosis in rats. Methods Sixty adult Wistar rats were included into 6 groups (n=10 in each):normal control group, model control group, Fufang Biejia Ruangan group, low- dose HTXY group, middle- dose HTXY group and high- dose HTXY group. The corre-sponding drugs were given for 6 weeks. After treatment, the hydroxyproline(Hyp) levels in hepatic tissues were detected by alkali hydrolysis method and the pathological changes of hepatic fibrosis were observed by HE staining and picric acid- sirius red staining. Results Compared to normal control and model control groups, the degree of hepatic fibrosis were significantly atten-uated in Fufang biejia ruangan group and HTXY decoction groups (P<0.05), and more markedly in middle- dose group. The Hyp levels in hepatic tissues were also significantly decreased in middle- dose HTXY group (P<0.05). Conclusion HTXY decoction can improve hepatic fibrosis and reduce hepatic tissue Hyp levels in rats with experimental hepatic fibrosis.关键词
化痰行瘀汤/肝纤维化/大鼠/组织病理学/HypKey words
Hua tan xing yu decoction/Hepatic fibrosis/Rats/Histopathology/Hydroxyproline引用本文复制引用
陈国中,徐珊,张永生,朱飞叶..化痰行瘀汤对肝纤维化大鼠组织病理学及羟脯氨酸含量的影响[J].浙江医学,2013,(16):1498-1501,4.
