浙江医学Issue(17)：1554-1556,3.
ER-α基因多态性与子宫内膜癌的相关性研究
Association of ER-α gene polymorphism with endometrial carcinoma
摘要
Abstract
Objective To assess the association of ER- α gene polymorphisms with endometrial cancer. Methods A case- control study was performed with 48 endometrial cancer patients and 96 matched controls. The ER- α- MSPⅠ polymor-phism sites were detected by using polymerase chain reaction- restriction fragment length polymorphism(PCR- RFLP). The asso-ciation between genotypes and endometrial cancer was estimated by odds ratios (ORs) and the 95% confidence intervals(CIs) calculated by unconditional logistic regression. Results The distribution frequency of genotype of ER- α- MSPⅠ site in en-dometrial cancer patients and controls was TT:58.3%and 31.2%, CC:10.4%and 24.0%, TC:31.2%and 44.8%, respectively;the frequency of al elic gene was T:74.0%and 53.6%, C:26.0%and 46.4%, respectively. There were significant differences in geno-type distributions between two groups (P<0.05), and the frequency of al elic C in endometrial cancer patients was lower than that of controls. Conclusion There may be association of ER- α- MSPⅠsite polymorphism with susceptibility of endometrial cancer.关键词
子宫内膜癌/ER- α基因多态性/易感性Key words
Endometrial carcinoma/ER- αgene polymorphisms/Susceptibility引用本文复制引用
谷杭芝,郑飞云,王金仙..ER-α基因多态性与子宫内膜癌的相关性研究[J].浙江医学,2013,(17):1554-1556,3.基金项目
温州市科技计划项目 （）
