浙江医学Issue(17)：1593-1595,1598,4.
ROC曲线评价M30和M65在非酒精性脂肪肝诊断中的价值
Serum M30 and M65 antigens for diagnosis of nonalcoholic fatty liver disease
魏建波 1刘琴 1蔡莹 2姜凯1
作者信息
- 1. 浙江省立同德医院检验科, 杭州,310012
- 2. 临安市中医院检验科
- 折叠
摘要
Abstract
Objective To assess the diagnostic value of serum M30 and M65 antigens in patients with non- alcoholic fatty liver disease (NAFLD). Methods One hundred and three patients with NAFLD were enrolled in the study, including 63 cased of simple hepatic steatosis (n=63) and 40 cases of non- alcoholic steato- hepatitis (NASH), and 26 healthy subjects were also in-cluded as controls. Serum levels of M30 and M65 antigens were detected with ELISA, and their diagnostic value for NAFLD was analyzed with receiver operating characteristic curves (ROC). Results The serum M30 and M65 levels in NAFLD were signifi-cantly higher than those in controls(164.0±87.5U/L vs 98.4±20.5U/L, P<0.01;and 546.0±167.4U/L vs 289.0±98.4U/L, P<0.01, respectively). In patients with NAFLS the serum M30 and M65 levels in NASH patients were significantly higher than those in sim-ple steatosis patients (189.4±82.5U/L vs 132.0±74.4U/L, P<0.01 and 624.0±183.4U/L vs 562.0±156.4U/L, P<0.05, respec-tively). The Area under curve (AUC) in ROC of M30 antigen for diagnosis NASH was 0.743, that of M65 was 0.669. The AUC of combined M30 and M65 for diagnosis of NASH was 0.878, and taking M30161.9U/L and M65 514.8U/L as cut- off values the sensitivity, specificity and accuracy were 94.5%, 85.5%and 88.9%respectively. Conclusion Serum M30 and M65 levels can be used in diagnosis of NASH in NAFLD patients, the combination of M30 and M65 are of better diagnostic value.关键词
ROC/M30/M65/凋亡/非酒精性脂肪肝Key words
ROC/M30/M65/Apoptosis/NAFLD引用本文复制引用
魏建波,刘琴,蔡莹,姜凯..ROC曲线评价M30和M65在非酒精性脂肪肝诊断中的价值[J].浙江医学,2013,(17):1593-1595,1598,4.
