肿瘤药学Issue(4)：282-285,296,5.DOI:10.3969/j.issn.2095-1264.2013.068
奥沙利铂治疗胃肠道肿瘤的不良反应及治疗方案分析
Analysis on the Treatment and Adverse Effects of Oxaliplatin for Gastrointestinal Tumor Patients
周爱民 1丛刘春 2徐俊华 1花红林 1瞿峰1
作者信息
- 1. 如东县第三人民医院，江苏 如东，226406
- 2. 如东县第一人民医院，江苏 如东，226406
- 折叠
摘要
Abstract
Objective The purpose is to explore the adverse reaction factors of oxaliplatin in the treatment of gastrointesti-nal tumor and to compare the effects of different clinical treatments. Methods Fifty-nine patients were divided into two groups. Patients in group A were given oxaliplatin on the first day, leucovorin and 5-fluorouracil on 1~7 days. Patients in group B were given nerve nutrition therapy and intravenous calcium gluconate before chemotherapy, then were given oxaliplatin on the first day and leucovorin and 5-fluorouracil on 1~7 days. The incidences of adverse reactions were compared between the two groups according to gender, age, primary tumor types and treatment options for patients. Results The adverse reaction incidence rates showed no significant differences between patients with different age and tumor types, P>0.05. The neurotoxicity reaction rates showed significant differences between patients with different genders, P<0.05. The neurotoxicity and allergic reaction rates of patients with different treatment options showed significant difference, P<0.05. Conclusion The incidence of adverse reaction of patients can be reduced and the therapeutic effects can be improved by reducing the dose of oxaliplatin and adding calcium glu-conate and neural nutrition or other preventive medicines as well.关键词
奥沙利铂/胃肠道肿瘤/不良反应/治疗方案Key words
Oxaliplatin/Gastrointestinal neoplasms/Adverse reaction/Treatment分类
医药卫生引用本文复制引用
周爱民,丛刘春,徐俊华,花红林,瞿峰..奥沙利铂治疗胃肠道肿瘤的不良反应及治疗方案分析[J].肿瘤药学,2013,(4):282-285,296,5.
