安徽医科大学学报2016，Vol.51Issue(6)：769-772,4.
隐丹参酮抑制恶性神经胶质瘤细胞C6增殖及对 JAK2-STAT3信号通路的影响
Cryptotanshinone inhibits proliferation of malignant glioma C6 cells and its influence on JAK2-STAT3 signal pathway
摘要
Abstract
Objective To evaluate the effect of cryptotanshinone ( CTS) on the proliferation of malignant glioma C 6 cells and its influence on JAK 2-STAT3 signal pathway .Methods MTT was used to evaluate the survival rate of CTS on C6 cells.Hochest staining and BrdU assay was used to detect the cell apoptosis and proliferation .Western blot was used to detect the expressions of p-JAK2 and p-STAT3(Tyr705).Results CTS inhibited C6 cells growth and proliferation significantly ( P<0.05 ) , but not induced apoptosis .CTS decreased phosphorylation of p-STAT3 (Tyr705), but not p-JAK2.Conclusion CTS may be a potential anti-proliferation agent of malignant glioma C6 cells and that its mechanism may be related to the inhibition of STAT 3 signaling .关键词
恶性神经胶质瘤/增殖/JAK2-STAT3信号通路Key words
malignant glioma/proliferation/JAK2-STAT3 signaling pathway分类
医药卫生引用本文复制引用
唐焕焕,沈晓燕,段小群,徐庆,苑博,张嫦丽,吕良..隐丹参酮抑制恶性神经胶质瘤细胞C6增殖及对 JAK2-STAT3信号通路的影响[J].安徽医科大学学报,2016,51(6):769-772,4.基金项目
国家自然科学基金（编号81460619）；广西自然科学基金青年项目 （）
