安徽医科大学学报2016，Vol.51Issue(6)：836-840,5.
YAP1和β-catenin 在大肠癌中的表达及相关性研究
Expression and relationship of YAP1 andβ-catenin in colorectal carcinoma
摘要
Abstract
Objective To investigate the expression of Yes-associated protein 1(YAP1 ) andβ-catenin in colorec-tal carcinoma tissues and their association with the clinicopathological features of colorectal carcinoma patients . Methods The expressions YAP1 andβ-catenin in human colorectal carcinoma and colorectal normal tissue (99 ca-ses of human colorectal carcinoma ,30 cases of colorectal normal tissues ) were detected by immunohistochemistry Envision two step method .Results The positive rate of YAP1 in CRC ( 56.57%) was higher than that in normal mucosa(16.67%)(χ2 =14.704,P<0.01) .The abnormal positive rate of β-catenin in CRC(51.52%)was high-er than that in normal mucosa(0%)(χ2 =25.559,P<0.01).The expression of YAP1 showed no significant cor-relation with sex , age,differentiation,infiltration,lymph node metastasis and Duke′s period.The nuclear β-catenin expression was correlated with the differentiation degree and depth of invasion (χ2 =6.641, 4.229,P<0.05).The cytoplasmic β-catenin expression was correlated with the differentiation degree (χ2 =6.761,P<0.05).The mem-branal β-catenin expression showed no significant correlation with clinicopathological parameters .The cytoplasmicβ-catenin expression and nuclear β-catenin expression was postively correlated with the nuclear YAP 1 expression and cytoplasmic/nuclear YAP1 expression ( P<0.05 ) .The nuclear β-catenin expression was postively correlated with the cytoplasmic YAP1 expression(P<0.05).Conclusion YAP1 and β-catenin proteins play important roles together in the carcinogehesis of CRC .The nuclear β-catenin expression may contribute to colorectal carcinoma prognosis judgement .关键词
大肠癌/YAP1/β-catenin/免疫组织化学Key words
colorectal carcinoma/YAP1/β-catenin/immunohistochemistry分类
医药卫生引用本文复制引用
陈顺华,尹玉,曹立宇,张聪,李玉洁..YAP1和β-catenin 在大肠癌中的表达及相关性研究[J].安徽医科大学学报,2016,51(6):836-840,5.基金项目
国家自然科学基金（编号81201536）；安徽省高校省级自然科学研究项目 （）
