安徽医科大学学报2016，Vol.51Issue(7)：1027-1031,5.
晚期胃癌含铂方案化疗疗效与 miR－192表达水平的研究
On the correlation between miR-192 expression and the efficacy of platinum-based chemotherapy in patients with advanced gastric carcinoma
摘要
Abstract
Objective To investigate the correlation between miR -192 expression in the tumor tissues and the effi -cacy of first-line platinum-based chemotherapy in the patients of advanced gastric carcinoma .Methods The miR-192 expression was measured by real -time quantitative PCR in the tumor tissues from 41 patients with advanced gastric carcinoma and in the adjacent non -tumorous normal tissues from 20 patients.All the enrolled patients were received platinum-based chemotherapy and the chemotherapeutic efficacy was evaluated .miR-192 expression level in tumorous and non-tumorous component and its correlation with clinicopathological characteristics and platinum -based chemotherapy efficacy were evaluated.Results The miR-192 expression was higher inside the tumor tissues than adjacent non -tumorous normal tissues (Z =-2.045,P =0.041) and its level in carcinomatous component was statistically correlated with the presence of liver metastasis (Z =-2.282,P =0.022),while independent of age, sex, ECOG score, tumor grade and drinking behavior .Thirty -nine patients were considered evaluable for ef -ficacy.There were CR in 1 case, PR in 7 cases, SD in 18 cases, and PD in 13 cases.ORR was 20.5% and DCR was 66.7%.miR-192 expression level was positively correlated with chemotherapy efficacy (rs = 0.156,P =0.035).Conclusion miR-192 expression in the tumor tissues is correlated with the short -term chemotherapeutic efficacy of patients with advanced gastric carcinoma treated with platinum -based chemotherapy.关键词
胃癌/微小 RNA/铂/化疗Key words
gastric carcinoma/microRNA/platinum/chemotherapy分类
生物科学引用本文复制引用
刘威,顾康生,李敏,宁洁,张逸寅,黄娜娜..晚期胃癌含铂方案化疗疗效与 miR－192表达水平的研究[J].安徽医科大学学报,2016,51(7):1027-1031,5.基金项目
安徽省自然科学基金(1408085MH203) （1408085MH203）
