安徽医科大学学报2016，Vol.51Issue(7)：1046-1048,1049,4.
静息态 fMRI研究遗忘型与小血管性轻度认知障碍功能连接密度变化
Resting-state fMRI study on changes of functional connectivity density in amnestic mild cognitive impairment and small vascular mild cognitive impairment
摘要
Abstract
Objective To observe the changes of functional connectivity density ( FCD) in amnestic mild cognitive impairment(aMCI) and small vascular mild cognitive impairment (svMCI) using resting-state fMRI.Methods 14 aMCI patients , 13 svMCI patients and 23 health controls ( HC ) participated in resting-state fMRI examinations . DPARSFA was used for data processing to get the FCD maps and SPM 8 was used for statistic analysis .Results In the right superior occipital gyrus , right precuneus , right superior parietal lobe , right parahippocampal gyrus and left inferior temporal gyrus , the FCD values were significantly different among the 3 groups.Compared with HC , aMCI presented FCD decreased in the right superior occipital gyrus , right precuneus and right superior parietal lobe , while svMCI showed increased FCD in the right parahippocampal gyrus .Compared with aMCI , svMCI showed FCD increase in the left inferior temporal gyrus .Conclusion There exist FCD differences among the 3 groups .svMCI shows different FCD compared with aMCI , which indiciates that there may be different neuropathology mechanisms between those two diseases .关键词
遗忘型轻度认知障碍/小血管性轻度认知障碍/功能连接密度/静息态功能磁共振Key words
amnestic mild cognitive impairment/small vascular mild cognitive impairment/functional connectivity density/resting-state functional MRI分类
医药卫生引用本文复制引用
李晓舒,王海宝,余永强,田仰华,周珊珊,李小虎,徐丽艳..静息态 fMRI研究遗忘型与小血管性轻度认知障碍功能连接密度变化[J].安徽医科大学学报,2016,51(7):1046-1048,1049,4.基金项目
国家自然科学基金(81171326) ,高等学校博士学科点专项科研基金联合课题(20123420110001) ,安徽省科技攻关项目(1301042202) （81171326）
