安徽医科大学学报2016，Vol.51Issue(7)：1053-1057,1058,6.
自体 DC－CIK 细胞治疗晚期实体瘤患者的疗效分析
Clinical efficacy of autologous DC-CIK cells therapy for patients with advanced solid tumors
摘要
Abstract
Objective To study the influence of immune system and clinical efficacy of DC -CIK cells therapy for patients with advanced solid tumors .Methods Sixty patients were divided into two groups .The treatment group was received two cycles’ reinfusion of DC-CIK cells, while the control group was not .The changes of proportional of immune cells and quality of life were compared before and after the treatment , and the clinical efficacy and ad-verse reactions were also detected.Results In the treatment group, the overall response rate was 0.00%, and the disease control rate was 36.67%.The ratios of CD4+T lymphocytes, NK and CIK cells were higher than before, but the ratio of CD8+T lymphocytes was less.Patients’ overall quality of life was improved and the adverse reac -tions were fever, allergies etc.In the control group, the ratios of CD4+T lymphocytes, NK and CIK cells are less than before, but the ratio of CD8+T lymphocytes was higher.Patients’ overall quality of life was decline .and the ratio of B lymphocytes in both groups didn’t change significantly.Conclusion DC-CIK cells therapy can improve the patients’ with advanced solid tumors immune function and general situations , which has a certain clinical effect and its adverse reactions are less , so it can be used as one option for the patients who suffer the failures of chemo -therapy and radiotherapy.关键词
树突状细胞/细胞因子诱导的杀伤细胞/晚期实体瘤/淋巴细胞亚群/生活质量Key words
dendritic cells/cytokine-induced killer cells/advanced solid tumor/lymphocyte subsets/quality of life分类
医药卫生引用本文复制引用
冉宝石,王伟,王刚,孙玉蓓,王保龙,季楚舒..自体 DC－CIK 细胞治疗晚期实体瘤患者的疗效分析[J].安徽医科大学学报,2016,51(7):1053-1057,1058,6.基金项目
国家自然科学基金(81172172) （81172172）
