中医学报2016，Vol.31Issue(6)：834-837,4.DOI:10.16368/j.issn.1674-8999.2016.06.233
野蔷薇根醇提物对动脉粥样硬化模型大鼠脂代谢、血钙及内皮功能的影响
Effect of Rosa Multiflora Thunb Extract on Lipid Metabolism, Serum Calcium and Endothelial Function of Rat Model of Atherosclerosis
摘要
Abstract
Objective:To discuss the mechanism of Rosa multiflora Thunb on lipid metabolism,serum calcium and endothelial function of rat model of atherosclerosis.Methods:Fifty SD rats were randomly divided into 5 groups,including blank control group,model group,Rosa multitlora Thunb extract group 4.15,8.30 g · kg-1,atorvastatin calcium tablet group 2.0 mg · kg-1;Rats in blank control group were fed with standard diet,rats in other groups were fed with high-fat diet,intraperitoneally injected vitamin D3 and dealed with immune injury.Intragastric administration for 90 days,then serum total cholesterol (CHO),triacylglycerol (TG),low density lipoprotein cholesterin (LDL-C),high density lipoprotein cholesterol (HDL-C),blood calcium (Ca),endothelin (ET),nitric oxide(NO) and nitric oxide synthase (NOS)in serum were detected.Liver index、cardiac index and arteriosclerosis index (AI) were calculated.Results:Compared with blank control group,liver index was (2.40 ± 0.19),AI was (0.75 ± 0.17),serum CHO was (1.39 ±0.23),LDL-C was (0.49 ±0.17),HDL-C was (0.82 ±0.14) mmol · L-1,Ca was (2.10 ±0.07) mmol· L-1,ET was (39.85 ± 7.99) mmol · L-1,the rats in model group showed remarkably increased liver index (0.88 ± 0.45),AI (6.89± 1.36),serum CHO (18.13±4.45) mmol · L-1,LDL-C was (16.15 ± 4.44) mmol · L-1,HDL-C was (2.73 ± 0.52) mmol · L-1,Ca was (4.44 ± 0.28) mmol · L-1,ET was (53.91 ± 9.83) ng · L-1 (P ＜ 0.05);In contrast to model group,the rats in intervention group showed remarkably decreased liver index:YT low dose group (4.38 ± 0.38),YT high dose group (4.23 ± 0.43),AL group (4.41 ± 0.45) (P ＜ 0.05) and the liver volume:the rats in AL group showed remarkably decreased AI (4.93 ± 1.19),C HO (11.36 ± 3.95) mmol · L-1 and LDL-C (9.78 ± 3.92) mmol · L-1 and ET (39.07 ± 8.98) ng · L-1 (P ＜ 0.05);the rats in YT high dose group showed remarkably decreased AI (4.35 ± 1.40),LDL-C (8.68 ± 2.22) mmol · L-1 and increased NOS (51.55 ± 5.83) U · L-1(P ＜ 0.05);the rats in YT low dose group showed remarkably decreased blood calcium (3.19 ± 0.32) mmol · L-1 (P ＜ 0.05).Conclusions:Rosa multiflora Thun extract could improve AS through regulating lipid metabolism、blood calcium and endothelial dysfunction.关键词
动脉粥样硬化/野蔷薇根醇提物/总胆固醇/三酰甘油/低密度脂蛋白胆固醇/高密度脂蛋白胆固醇/血钙/内皮功能/大鼠Key words
atherosclerosis/Rosa multiflora Thunb extract/total cholesterol/triglyceride/low density lipoprotein cholesterol/high density lipoprotein cholesterol/calcium/endothelial function/rat分类
医药卫生引用本文复制引用
李开言,黄霞,孙为,王晓丽,周红艳,张薇,张雪侠..野蔷薇根醇提物对动脉粥样硬化模型大鼠脂代谢、血钙及内皮功能的影响[J].中医学报,2016,31(6):834-837,4.基金项目
河南省中医药研究院中医心病重点专科支持项目(1304489) （1304489）
