酸枣仁汤对DL-4-氯苯基丙氨酸所致失眠的药效学研究OA
The Research into Efficacy of Decoction of Semen Ziziphi Spinosae in Treating Insomnia due to DL-4-chlorobenzene alanine of Rats
目的:探讨酸枣仁汤治疗DL-4-氯苯基丙氨酸所致失眠大鼠的药理作用机制.方法:将50只大鼠随机分为正常对照组、模型组、地西泮组、酸枣仁汤大剂量组、酸枣仁汤小剂量组,每组10只,适应性喂养2d,2d后开始给药,并每天称体质量,大剂量组灌胃给予酸枣仁汤12 g·kg-1,小剂量组灌胃给予酸枣仁汤6g·kg-1,地西泮组灌胃给予地西泮溶液1 mg·kg-1,正常对照组与模型组根据体质量灌胃等体积蒸馏水.建立DL-4-氯苯基丙氨酸(PCPA)大鼠失眠模型…查看全部>>
Objective:To explore the pharmacological action mechanism of Decoction of Semen Ziziphi Spinosae in treating insomnia due to DL-4-chlorobenzene alanine of rats.Methods:Fifty rats were randomly divided into the normal control group,the model group,the diazepam group,the group of large-dosage Decoction of Semen Ziziphi Spinosae,and the group of small-dosage Decoction of Semen Ziziphi Spinosae,with 10 cases in each group.They were fed adaptively for 2 days,then…查看全部>>
张军武;田凡;邹文信;张亚宁;张胜威
陕西中医药大学,陕西咸阳712046陕西中医药大学,陕西咸阳712046陕西中医药大学,陕西咸阳712046陕西中医药大学,陕西咸阳712046北京中医药大学,北京100102
中医学
酸枣仁汤DL-4-氯苯基丙氨酸失眠大鼠
Decoction of Semen Ziziphi SpinosaeDL-4-chlorobenzene alanineinsomniarats
《河南中医》 2016 (6)
985-987,3
2011年陕西省科技厅社会发展攻关项目(编号:2011K16-04-09)2012年陕西省咸阳市科技计划项目(编号:2012K16-01-4)
评论