吉首大学学报（自然科学版）2016，Vol.37Issue(3)：85-89,5.DOI:10.3969/j.cnki.jdxb.2016.03.018
黑胸大蠊水提取物对H22荷瘤小鼠肿瘤的抑制作用
Effect of Periplaneta Fuliginosa Aqueous Extract on Tumor Inhibition Action and Immune organs in H22 Bearing Mice
摘要
Abstract
The effects of Periplaneta fuliginosa aqueous extract on tumor inhibition action and immune organs in H22 bearing mice were investigated.To establish the H22cell tumor model,the H22cells were in-oculated subcutaneously in Kunming mice which were randomly divided into normal group,model group, cyclophosphamide group,Periplaneta fuliginosa aqueous extract high dosage group,medium dosage group and low dosage group.From tumor volume,tumor mass,tumor inhibition rate,organ index and tumor tissue HE stain,the effects of Periplaneta fuliginosa aqueous extract on tumor and immune organs were observed.The results showed that in Periplanetafuliginosa aqueous extract low dose group,medi-um dose group and high dose group,the tumor inhibition rates were 20.72%,29.24%,43.16% respec-tively.The high dose group had significant difference compared with model group(P<0.05).Compared with the normal group,the spleen index of each dose group increased,and the high and middle dose group had significant difference (P<0.05).The thymus index of each dose group decreased,but there was no significant difference compared with model group (P>0.05).HE staining showed that in the high,medi-um and low dose group of Periplaneta fuliginosa aqueous extract,tumor tissue had different degrees of necrosis compared with model group.It is concluded that Periplaneta fuliginosa aqueous extract shows inhibitory effect on the growth of tumor in H22 bearing mice without obvious damaging effect on immune organ.关键词
黑胸大蠊/水提取物/H22荷瘤小鼠/抗肿瘤作用Key words
Periplanetafuliginosa/aqueous extract/H22 bearing mice/antitumor activity分类
医药卫生引用本文复制引用
黄利,吴仕筠..黑胸大蠊水提取物对H22荷瘤小鼠肿瘤的抑制作用[J].吉首大学学报（自然科学版）,2016,37(3):85-89,5.基金项目
湖南省中医药管理局重点资助项目（201333）；湖南省教育厅科学研究资助项目（10A097）；湖南省科技厅科技计划资助项目（2012SK3149）；吉首大学校级课题资助项目（14JDY037）；湖南省大学生研究性学习和创新性实验计划资助项目 （）
