临床小儿外科杂志2016，Vol.15Issue(3)：238-240,3.DOI:10.3969/j.issn.1671-6353.2016.03.010
经胸室间隔缺损封堵术围术期氨基末端脑钠肽前体的变化研究
Changes of N-terminal probrain natriuretic peptide during perioperative period of mini-invasive occlu-sion of ventricular septal defect
李青 1崔传玉 1范洁 1宋航 1张冲 1刘建国 1何飞 1李迎1
作者信息
- 1. 江苏省徐州市儿童医院 江苏省徐州市，221006
- 折叠
摘要
Abstract
Objetive To explore the effects of mini-invasive occlusion for ventricular septal defect (VSD)on N-terminal probrain natriuretic peptide (NT-proBNP). Methods A total of 30 VSD children un-derwent mini -invasive occlusion.And serum NT-proBNP was detected by dry-type fluorescent quantitative an-alyzer at a total of 8 timepoints (i.e.baseline,1 h,2 h,6 h,12 h,24 h,48h &7 days post-operation).The changes of serum NT-proBNP concentration were compared at each timepoint.Results All cases had a remov-al of intubation within a mean time of 3.5 ±2.1 h postoperation and a hospital discharge within a mean time of 7.1 ±1.5 d.NT-proBNP had no obvious change from finishing moment of operation to postoperative 6 h;NT-proBNP significantly increased untill 12 -24 h postoperatively.And their comparisons with other timepoints were statistically significant (P <0.05);Then NT-proBNP gradually returned to preoperative levels. Conclu-sions Mini-invasive occlusion may cause reversible minor myocardial damage.Serum NT-proBNP may detect myocardial ischemia and anoxia early and provide scientific rationales for preventing and treating postoperative complications and promoting rapid recovery.Thus it may be used as a clinical screening tool for myocardial injury.关键词
室间隔缺损/手术期间/心肌损伤Key words
Heart Septal Defects,Ventricular/Intraoperative Period/Myocardial Injury引用本文复制引用
李青,崔传玉,范洁,宋航,张冲,刘建国,何飞,李迎..经胸室间隔缺损封堵术围术期氨基末端脑钠肽前体的变化研究[J].临床小儿外科杂志,2016,15(3):238-240,3.
