临床眼科杂志2016，Vol.24Issue(3)：222-225,4.DOI:10.3969/j.issn.1006-8422.2016.03.010
HRT-Ⅲ、SD-OCT、Humphrey自动视野计和视网膜电图明视负波反应在 POAG 诊断中的应用
The application of HRT-Ⅲ、SD-OCT、Humphrey VF and Photopic negative response of Electroretinogram in primary open-angle glaucoma diagnosis
摘要
Abstract
Objective To explore the diagnostic values of Heidelberg Retina Tomography ( HRT-Ⅲ) , Spectral-domain optical coherence tomography (SD-OCT),Humphrey Automated Perimetry and Electroretinogram Photopic Negative Response(PhNR) in Primary Open-angle Glaucoma (POAG) patients.Methods 100 cases (100 eyes) of POAG pa-tients and 50 cases (50 eyes) of normal subjects were examined by HRT-Ⅲ, SD-OCT, Humphrey Automated Perimetry and PhNR in our hospital .The results were analyzed by using SPSS 17.0 software, single sample t-test and ROC curve a-nalysis.Results The area under the ROC curve of SD-OCT average RNFLT is the largest (AUC=0.974), which has the highest diagnostic value to POAG;The area under the ROC curve of white -white PhNR amplitude is 0.954, the diagnostic value to POAG is secondly to the average RNFLT of SD-OCT.The sensitivity of the average RNFLT of SD-OCT and white-white PhNR amplitude are 95%, 90%, 93.3%and 76.7%separately in setting specifity≥80%and≥95%.The area under the ROC curve of the others parameters were greater than 0.7 , and have certain diagnostic values to POAG .Con-clusions In POAG patients, the average retinal nerve fiber layer thickness of SD-OCT has the highest diagnostic values and white -white PhNR amplitude has the second one .The four equipments above have assessed the optic nerve damage characteristics of the structure and function from different view angles , which helps to guide the diagnosis and treatment of glaucoma .关键词
HRT-Ⅲ/SD-OCT/视野/视网膜电图明视负波/原发性开角型青光眼Key words
Heidelberg retina tomography Ⅲ/Spectral-domain optical coherence tomography/Humphrey Automa-ted Perimetry/Electroretinogram photopic negative response/Primary open-angle glaucoma引用本文复制引用
申晓丽,李强,赵军,黄丽娜..HRT-Ⅲ、SD-OCT、Humphrey自动视野计和视网膜电图明视负波反应在 POAG 诊断中的应用[J].临床眼科杂志,2016,24(3):222-225,4.基金项目
广东省医学科学技术研究基金项目（ A2015315）；深圳市创新委基础研究项目 （）
