中国临床保健杂志2016，Vol.19Issue(4)：337-342,6.DOI:10.3969/J.issn.1672-6790.2016.04.001
养血益气、补肾通络法治疗强直性脊柱炎的疗效观察
Efficacy of Yi Qi,Bushentongluo therapy on Ankylosing Spondyliti
摘要
Abstract
Objective To study the effect of traditional Chinese medicine of YangXue YiShen and QuXie TongLuo regulating immune in patients with AS and evaluate its curative effect and safety.Methods 80 patients with AS were which randomly assigned for traditional Chinese medicine of YangXue YiShen and QuXie TongLuo as the re-search group (n =40)and Sulfasalazine as the control group (n =40).The total course of treatment was 8 weeks.After the end of treatment,the symptoms,signs,laboratory examination,quality of life and psychological status of patients with ankylosing spondylitis were observed.Results (1)The comparison of clinical curative effect in tow groups.The ASAS 20 and BASDAI 50 of the research group that the group of kidney nourishing and blood and Quxie Tongluo were respec-tively 80.0% and 70.0%,and the control group were respectively 75.0%,and 62.5%.Compared with the control <br> group,the curative effect of the research group was higher,but there was no statistically significant difference between the two groups(P >0.05).(2)The comparison of TCM syndrome curative effect in two groups between before and after treatment.The research group total effective rate 90.0%,the control group the total effective rate was 82.5%.There was no significant differenceabout the total effective rate in two groups(P >0.05).But compared with the control group (45.0%),the effective rate of the research group(70.0%)was significantly increased,and had statistical significance (P <0.05).(3)The changes of traditional Chinese medicine symptom integral of before and after treatment in the two groups.Team in patients with lower gas less lazy words,heart palpitations,chest tightness,shortness of breath integral significantly better than that of control group (P <0.05).(4)The change of the main symptoms and signs before and af-ter treatment in two groups.After treatment with a significant reduction in the integration of the two group.Compared with the control group after treatment,the team on the improvement of BAS FI,BAS -G integral significantly better than that of control group (P <0.05).(5)The change of the quality of life,and anxiety,depression,mood of before and after treat-ment in two groups.Compared with the control group after treatment,the team and the quality of life after treatment the total integral dimension score significantly increased (P <0.01 ),SAS,SDS,significantly reduced (P <0.01 ).(6) Changes of laboratory indexes before and after treatment in both groups.Compared with before treatment,C3 of the re-search group was significantly higher after treatment;ESR,hs-CRP,IgG decreased;ESR,hs-CRP of control group sig-nificantly reduced (P <0.05 or P <0.01);Compared with control group,the level of IgG significantly reduced in the research group (P <0.05 or P <0.01).Conclusion The Yangxue Yishen,Quxie Tongluo obviously improved compre-hensive indexes of the signs and symptoms,syndromes,functional activity,quality of life,laboratory examination,immu-nology etc of AS patients.Curative effect is comparable to western medicine SASP or better than the latter,effect is satis-fying.关键词
脊柱炎,强直性/补肾养血/通络/中草药/柳氮磺胺吡啶Key words
Spondylitis,ankylosing/Reinforcing kidney nour blood/Dredging collaterals/Drugs,Chinese herbal/Sulfasalazine分类
医药卫生引用本文复制引用
谌曦,黄传兵,万磊,唐昆,周正新,范海霞,刘天阳,刘健..养血益气、补肾通络法治疗强直性脊柱炎的疗效观察[J].中国临床保健杂志,2016,19(4):337-342,6.基金项目
国家自然科学基金面上项目（81173211／H2708）；国家科技部“十二五”国家科技支撑计划分课题（2012BA126B02）；全国名老中医工作室；新安医学防治中医疑难病临床研究 （）
