摘要
Abstract
Objective To evaluate the relationship between serum ferritin (SF)and glucose and lipoprotein lipids metabolism,oxidative stress,insulin resistant in type 2 diabetes mellitus.Methods Ninty subjects were select-ed,including 28 controls,30 impaired glucose tolerance(IGT)and 32 type 2 diabetes.The general data (age,height, weight and family history)were collected.The levels of serum ferritin and fasting insulin(FIns)were detected by im-muno-turbidimetry.Serum creatinine(SCr),lipid and fasting plasm glucose(FPG)were detected by automatic bio-chemical analazer.HbA1 c was detected by high pressure liquid chromato-graphy.SOD,MDA and GSH-Px were detec-ted by colorimetry.Results The levels of serum ferritin in patients with type 2 diabetes were significantly higher than that in impaired the glucose tolerance group and healthy subjects[(184.2 ±3.12)μg/L VS.(171.5 ±2.61)μg/L VS.(104.1 ±1.87)μg/L],there were statistical differences(P <0.05).Serum ferritin was positively correlated with FIns,index of insulin resistance(HOMA-IR),TG,TC,HbA1 c and MDA (r =0.7145,P <0.05;r =0.5637,P <0.05;r =0.6358,P <0.05;r =0.8320,P <0.05;r =0.5283,P <0.01;r =0.6243,P <0.01),and negatively correla-ted with SOD,GSH-Px(r =0.3413,P <0.05;r =0.3153,P <0.05).Conclusions The iron stores is increased in pa-tients with type 2 diabetes,iron overload can cause oxidative stress and insulin resistance.关键词
糖尿病,2 型/铁蛋白质类/葡萄糖代谢障碍/危险因素Key words
Diabetes mellitus,type 2/Ferritins/Glucose metabolism disorders/Risk factors分类
医药卫生
