中国临床保健杂志2016，Vol.19Issue(4)：366-368,3.DOI:10.3969/J.issn.1672-6790.2016.04.010
吡格列酮联合二甲双胍对初诊2型糖尿病患者血清视黄醇结合蛋白4水平的影响
Effect of pioglitazone combined with metformin on serum retinol-binding protein 4 (RBP4)in patients with newly diagnosed type 2 diabetes
摘要
Abstract
Objective To observe the effects of pioglitazone combined with metformin on serum RBP4 level in patients with newly diagnosed type 2 diabetes mellitus(T2DM)and examine the relationship between RBP4 and T2DM, and the treatment mechanism of medicine.Methods Sixty patients with newly-diagnosed T2DM (A group)were ran-domly divided into two groups,30 cases were treated with metformin(A1 group),30 cases were treated with pioglitazone and metformin(A2 group)for 12 weeks,30 health examination clients were selected as control(B group).Fasting plas-ma glucose(FBG),glycosylated hemoglobin (HbAl c),RBP4,blood fat,fasting plasma insulin(FIns),the body mass index (BMI),the waist-hip-ratio(WHR)and HOMA-insulin resistance index (HOMA-IR),Homeβcell function index (HBCI)before the treatment.Results (1 )The serum RBP4 level of A group was higher than B group (P <0.05).(2)After the treatment, the FPG,HbAl c,FIns,RBP4,HOMA-IR,BMI,WHR,Low density lipoprotein cho-lesterol (LDL-C)were significantly decreased in A1 and A2 groups (P <0.05),and the effect of the A2 group was su-perior to that in the A1 group.HBCI was significantly increased compard with that befor treatment(P <0.05),there were no statistical differences between two groups after treatment(P >0.05).Conclusions The combined treatment with metformin and pioglitazone can decrease plasma glucose level and improve IR and β-cell function better.关键词
糖尿病,2 型/视黄醇结合蛋白质类/二甲双胍/噻唑烷二酮类Key words
Diabetes Mellitus,Type 2/Retinol-binding proteins/Metformin/Thiazolidinediones分类
医药卫生引用本文复制引用
陈红梅,李洪彬,邱谷,戴士荣,汤永新..吡格列酮联合二甲双胍对初诊2型糖尿病患者血清视黄醇结合蛋白4水平的影响[J].中国临床保健杂志,2016,19(4):366-368,3.基金项目
江苏省南通市科技计划资助项目 （）
