中国临床保健杂志2016，Vol.19Issue(4)：404-408,5.DOI:10.3969/J.issn.1672-6790.2016.04.023
正加速度暴露对不同程度冠状动脉狭窄小型猪血浆儿茶酚胺和交感神经系统活性的影响
Effects of positive acceleration on sympathetic nervous activity and plasma catecholamine in miniature pig model with different coronary artery stenosis
摘要
Abstract
Objective To study the effects of positive acceleration (+Gz)on sympathetic nervous activity and plasma catecholamine in miniature pig model with different coronary artery stenosis.Methods Twenty-eight Obama miniature pigs were distributed to mild stenosis (Less than 50%,n =7)group,moderate stenosis (50% ~69%,n =7)group,severe stenosis (more than 70%,n =7)group,and sham-operation control group (n =7).The left anterior descending branch wire cerclage method was adopted for establish animal model of coronary artery steno-sis.We observed the effects of intermittent high +Gz exposure on heart rate and plasma adrenaline (Ad),norepi-nephrine (NE)and dopamine (DA)levels of miniature pigs with different coronary artery stenosis.Results The basal heart rate of severe stenosis group was significant higher than that in the normal control group and mild stenosis group (P <0.05).The heart rate of each group was significantly increased at immediately and 10 minutes after high+Gz exposure.Compare with control group and mild stenosis group,the heart rate of moderate and severe stenosis group were significantly increased.Furthermore,the duration of heart rate increase fast in severe stenosis group was more than 30 minutes after exposure.The plasma Ad,NE levels of severe stenosis groups were significant higher than the control and mild stenosis group (P <0.01)before exposure.Plasma Ad and NE levels in all groups were signifi-cantly increased at immediately and 10min after exposure(P <0.01).The plasma Ad and NE levels return to normal <br> at 30min after exposure in control and mild stenosis group,and the plasma Ad and NE of severe stenosis group contin-ued more than 30 minutes (P <0.01). Plasma DA of each group was significantly increased at once after +Gz ex-posure and return to normal at 10min after exposure(P <0.05.There was significantly increased plasma DA levels in severe stenosis group than the other group at 10min after exposure(P <0.05).Conclusion +Gz exposure can acti-vate sympathetic nervous system and increase plasma catecholamine (Ad,NE and DA)levels in miniature pig model, and the effects were much stronger in miniature pig with coronary artery stenosis more than 50% .关键词
冠状动脉狭窄/儿茶酚胺类/交感神经系统/模型,动物Key words
Coronary stenosis/Catecholamines/Sympathetic nervous system/Models,animal分类
医药卫生引用本文复制引用
张颖,罗惠兰,刘兴德,田建伟..正加速度暴露对不同程度冠状动脉狭窄小型猪血浆儿茶酚胺和交感神经系统活性的影响[J].中国临床保健杂志,2016,19(4):404-408,5.基金项目
全军“十二五”重点课题 （）
