环境与职业医学2016，Vol.33Issue(6)：542-546,5.DOI:10.13213/j.cnki.jeom.2016.16138
周围血5-羟色胺与手传振动接触水平及末梢血管损伤的相关性
Correlation of Peripheral Blood 5-Hydroxytryptamine with Hand-Arm Vibration Exposure and Peripheral Vascular Damage
摘要
Abstract
[Objective] To explore the correlation of peripheral blood 5-hydroxytryptamine (5-HT) levels with vibration exposure levels and peripheral vascular damage in hand-ann vibration exposed workers.[Methods] Seventy-seven workers exposed to hand-ann vibration from a sports equipment manufacturing company in Guangdong were selected for this study.General information,upper limb symptoms,and vibration-induced white finger (VWF) of the workers were collected by questionnaire.Cumulative vibration exposure level (CVEL) was calculated through on-site tested hand-ann vibration levels of the selected workers.Level of 5-HT in peripheral blood was detected by enzyme-linked immunosorbent assay.Cool water loading test (CWLT) was also conducted for the workers.The association of 5-HT level with hand-arm vibration exposure level and peripheral vascular damage was analyzed using binary non-conditional logistic regression models.[Results] The high CVEL group showed a higher 5-HT level than the low CVEL group (z=-2.352,P=0.034).The 5-HT level in the abnormal CWLT group was much higher than that in the normal CWLT group (z=-3.211,P=0.001).After adjusted for age,smoking,and drinking,according to the logistic regression model,5-HT level was associated with CVEL and CWLT:ORs (95％CIs) were 3.17 (1.12,8.94) for high CVEL vs.low CVEL and 7.34 (1.44,37.30) for abnormal CWLT vs.normal CWLT.The 5-HT level was not correlated with VWF results with OR (95％CI) as 1.92 (0.74,5.00).[Conclusion] The results suggests that hand-arm vibration exposure might result in elevated 5-HT levels,and the level of 5-HT correlates to vibration exposure level or hand peripheral vascular damage degree.关键词
手传振动/5-羟色胺/末梢血管损伤/振动性白指/冷水复温试验/累积振动接触水平Key words
hand-arm vibration/5-hydroxytryptamine/peripheral vascular damage/vibration-induced white finger/cool water loading test/cumulative vibration exposure level分类
医药卫生引用本文复制引用
郎丽,林瀚生,陈青松,肖斌,曾繁松..周围血5-羟色胺与手传振动接触水平及末梢血管损伤的相关性[J].环境与职业医学,2016,33(6):542-546,5.基金项目
广东省科技计划项目(编号:2014A020212733) （编号:2014A020212733）
广东省医学科学技术研究基金项目(编号:A2014078) （编号:A2014078）
广东省中医药局科研项目(编号:20142004) （编号:20142004）
