环境与职业医学2016，Vol.33Issue(6)：610-614,5.DOI:10.13213/j.cnki.jeom.2016.15590
环境毒理学研究的重要模式生物——斑马鱼
Zebrafish: An Important Model System for Toxicological Research of Studies on Environmental Chemicals
摘要
Abstract
Zebrafish has been widely used in monitoring and evaluation of environmental chemicals,and received recognition from the Organization for Economic Cooperation and Development (OECD),the International Organization for Standardization (ISO),and other authorities.This article described the advantages using zebrafish in environmental toxicology studies;reviewed that it as a widely used model seconded to mice was used in a series of environmental toxicology related studies,including developmental toxicity and teratogenicity,carcinogenic toxicity,embryonic toxicity,cardiovascular toxicity,neural and behavioral toxicity,especially reproductive toxicity;as well as proposed a wide prospect of application in hazard identification and risk assessment for environmental chemicals.In addition,because of its small embryonic and larval body,zebrafish is a suitable model system for high content analysis of chemicals and drugs,and combining techniques of transgenics,genomics,and proteomics,it can be better used in mechanism study of environmental toxicology.关键词
斑马鱼/环境化学物/模式生物/环境毒理学研究/风险评估/高内涵分析Key words
zebrafish/environmental chemical/model organism/environmental toxicology research/risk assessment/high content analysis分类
医药卫生引用本文复制引用
孙冰,许慧慧,黄超,丁训城,李卫华,胡晶莹..环境毒理学研究的重要模式生物——斑马鱼[J].环境与职业医学,2016,33(6):610-614,5.基金项目
国家自然科学基金(编号:31540038) （编号:31540038）
上海市科委实验动物研究专项(编号:15140901200) （编号:15140901200）
上海市第四轮公共卫生三年行动计划重点学科建设计划——环境卫生学与劳动卫生学(编号:15GWZK0201) （编号:15GWZK0201）
上海市计划生育科学研究所青年科技创新基金(编号:Q.2014-4) （编号:Q.2014-4）
上海市青年科技英才杨帆计划(编号:15YF1410000) （编号:15YF1410000）
