四川精神卫生2016，Vol.29Issue(3)：211-215,5.DOI:10.11886/j.issn.1007-3256.2016.03.005
单双相抑郁患者的情感气质特征及其与抗抑郁治疗反应的关系
Characteristics of affective temperaments and their relations with antidepressant treatment responses in unipolar depression and bipolar depression patients
林康广 1卢睿 1陈玲玉 1陈琨 1欧阳惠怡 1党亚梅 1徐贵云1
作者信息
- 1. 广州医科大学附属脑科医院，广东 广州 510370
- 折叠
摘要
Abstract
Objective To explore the differences in affective temperaments between unipolar depression,bipolar I disorder and bipolar II disorder patients,and to find relations between affective temperaments and responsesto antidepressant treatment in the major affective disorders. Methods In a semi - naturalistic six - week trial,332 patients with unipolar depression,116 patients with bipolar I disorder and 152 patients with bipolar II disorder suffering from a major depressive episode were treated with antidepressant treatment(and a mood stabilizer only for bipolar patients). All of the patients were recruited from the Guangzhou Brain Hospital and the First Affiliated Hospital of Jiˊnan University. Their affective temperaments were assessed by the Chinese TEMPS - A(Temperament Evaluation of Memphis Pisa Paris and San Diego - Auto questionnaire)and the severity of depression by the Hamilton Depression Scale- 17 item(HAMD - 17). Primary outcome measures were score - reducing rate of HAMD - 17 at the 4th and 6th week compared with baseline. Results Patients with bipolar I disorder score was significantly higher than patients with unipolar depression and patients with bipolar II disorder on the hyperthymic temperament subscale(F = 6. 562,P = 0. 002). Patients with bipolar II disorder score was significantly higher than unipolar depression disorder patients on the cyclothymic temperament subscales(F = 12. 89,P < 0. 01). The score - reducing rate of HAMD - 17 at the 6th week in patients with dominant hyperthymic temperament was better than patients without the dominant hyperthymic temperament(F = 6. 44,P = 0. 011). Conclusion The hyperthymic temperament may be overrepresented inpatients with bipolar I disorder,while the cyclothymic temperament may be overrepresented in patients with bipolar II disorder. The hyperthymic temperament was measured by TEMPS - A may be assist in predicting antidepressant treatment response in patients with major affective disorders suffering a major depressive episode.关键词
单相抑郁,双相抑郁/情感气质问卷/汉密尔顿抑郁量表Key words
Unipolar depression/Bipolar Depression/TEMPS - A/HAMD分类
医药卫生引用本文复制引用
林康广,卢睿,陈玲玉,陈琨,欧阳惠怡,党亚梅,徐贵云..单双相抑郁患者的情感气质特征及其与抗抑郁治疗反应的关系[J].四川精神卫生,2016,29(3):211-215,5.
