药学研究2016，Vol.35Issue(7)：376-378,389,4.DOI:10.13506/j.cnki.jpr.2016.07.002
三唑硫酮双席夫碱类衍生物的合成及其抗肿瘤活性研究
Synthesis and antitumor activity evaluation of the derivatives of 1,2,4 - triazole -5 - thione bis - schiff base
摘要
Abstract
Objective To design and synthesize a series of new derivatives of 1,2,4 - triazole - 5 - thione bis - schiff base and detect their antitumor activities in vitro. Methods the target molecules(7a ~ 7g)were synthesized by a series of reaction. The structures were characterized by 1 H - NMR and IR,and the growth inhibitory activities in vitro were evaluated by MTT assay against HeLa,HCT116 and BEL - 7402 cells. Results Compared with the positive control DDP,compound 7a,7b,7d,7e and 7g expressed significant stronger anti - proliferation effects against HCT116 cells,and 7a and 7d showed obvious inhibitory activities against HeLa cells,and BEL - 7402 cells,7d displayed the most significant inhibitory activity. Conclusion Compound 7d expressed significant anti - tumor activities in vitro against the three kinds cancer cells. Howev-er,the other compounds showed different inhibitory activities against tumor cell lines obtained from different tissues.关键词
1,2,4 - 三唑 - 5 - 硫酮衍生物/席夫碱/抗癌活性/噻唑蓝法/顺铂Key words
1,2,4 - triazole - 5 - thione derivatives/Schiff base/Antitumor activity/MTT assay/Cisplatin分类
药学引用本文复制引用
李敏,张玉娜,田玉顺..三唑硫酮双席夫碱类衍生物的合成及其抗肿瘤活性研究[J].药学研究,2016,35(7):376-378,389,4.基金项目
国家自然科学基金（No.81260226）；*为共同第一作者 （）
