世界中医药2016，Vol.11Issue(6)：1114-1118,5.DOI:10.3969/j.issn.1673-7202.2016.06.048
NMDA 受体 NR2B 亚基在慢性内脏痛敏及针灸治疗中的作用
Effects of NR2B Subsets of NMDA Receptor in Acupuncture Treatment For Chronic Visceral Pain
摘要
Abstract
N-methyl-D-aspartate receptor (NMDAR)has a variety of different subsets that are located differently on the central nerve.It involves in the transmission of signals in the body and regulates the excitability of neurons,such as mediating development of somatic and visceral pain.The NR2B subset of NMDAR is mostly common researched in its pain-related mechanism.Also,vis-ceral pain is a common clinical symptom,which was induced by mechanical and chemical stimulation to the sensory nerve endings of the organs and chest and abdominal walls or local ischemia,smooth muscle spasm and retained metabolite.Electric acupuncture was proved to have significant effect in the treatment of visceral pain and studies found that electric acupuncture can regulate NM-DA receptors,especially NR2B subset,revealing a potential analgesia target of electric acupuncture.This article analyzed the struc-ture,function,and mechanism of NR2B subset and discussed its mechanism in reliving chronic visceral pain on the basis of the TCM(traditional Chinese medicine)researches in this field in recent years.关键词
NMDA 受体/NR2B/内脏痛/针灸Key words
NMDA receptor/NR2B/Visceral pain/Acupuncture分类
医药卫生引用本文复制引用
翁志军,王立东,季亚婕,谭琳蓥,谢恒如,刘慧荣,吴焕淦..NMDA 受体 NR2B 亚基在慢性内脏痛敏及针灸治疗中的作用[J].世界中医药,2016,11(6):1114-1118,5.基金项目
国家自然科学基金项目（编号81202752）；国家重点基础研究发展计划（“973”计划）项目资助（编号2015CB554500）；上海市卫计委项目资助 （）
