疑难病杂志2016，Vol.15Issue(7)：710-712,3.DOI:10.3969/j.issn.1671-6450.2016.07.013
WNT 信号通路抑制因子－1和β连环蛋白在肾透明细胞癌中的表达及临床意义
The expression and clinical significance of WIF-1 andβ-catenin in clear-cell renal cell carcinoma
摘要
Abstract
Objective To investigate the expression of WIF -1(WNT inhibitory factor-1,WIF-l) and β-catenin in clear-cell renal cell carcinoma (ccRCC), and their correlations with clinical stage and pathological grading of renal cell carci -noma of renal cell carcinoma.Methods 102 patients with ccRCC who received radical resection in the Department of Urolo -gy, Shengjing Hospital of China Medical University from February 2010 to June 2015 were selected as the research subjects . Immunohistochemistry SP was used to detect the expression of WIF -1 and β-catenin in 102 cases of renal cell carcinoma tis-sues and the corresponding adjacent normal renal tissues .Results The difference of WIF-1 expression between ccRCC tissues and normal tissues were significantly statistical (5.97 ±1.96 vs.112.2 ±18.6, t =3.104, P <0.05), and β-catenin was (157.1 ±17.2 vs.102.1 ±18.7, t =4.015, P <0.05).The WIF-1 expression was negatively correlated with the clinical stage ( r =-0.542, P <0.05) and the pathological classification ( r =-0.476, P <0.05) of ccRCC.The β-catenin ex-pression was positively correlated with the clinical stage ( r =0.511, P <0.05) and the pathological classification ( r =0.562, P <0.05) of ccRCC.The expression of WIF-1 and β-catenin was negatively correlated in renal cell carcinomas ( r =-0.425, P <0.01).Conclusions The decreasing of WIF-1 expression and the increasing of β-catenin expression are relat-ed with the clinical stage and the pathological grading of RCC , and has a certain reference significance to the prognosis evalua -tion of ccRCC, and can provide a possible target therapy for the treatment of RCC .关键词
肾透明细胞癌/WNT 通路抑制因子-1/β连环蛋白Key words
Clear-cell renal cell carcinoma/WNT inhibitory factor-l/Beta catenin引用本文复制引用
李波,宋永胜,张超,司青乐..WNT 信号通路抑制因子－1和β连环蛋白在肾透明细胞癌中的表达及临床意义[J].疑难病杂志,2016,15(7):710-712,3.基金项目
辽宁省自然科学基金资助项目 （）
