中国当代儿科杂志2016，Vol.18Issue(7)：573-576,4.DOI:10.7499/j.issn.1008-8830.2016.07.001
大肠杆菌与肺炎链球菌所致儿童化脓性脑膜炎临床特点对比分析
Clinical features of childhood purulent meningitis caused by Escherichia coli and Streptococcus pneumoniae：a comparative analysis
韩慰 1蒋莉 1马建南 1宋晓洁 1何蓉1
作者信息
- 1. 重庆医科大学附属儿童医院神经内科 / 儿童发育疾病研究教育部重点实验室 /儿童发育重大疾病国家国际科技合作基地 / 儿科学重庆市重点实验室，重庆 400016
- 折叠
摘要
Abstract
Objective To investigate the differences in clinical features of childhood purulent meningitis (PM) caused by Escherichia coli and Streptococcus pneumoniae, and to provide help for the selection of antibiotics for PM children with unknown etiology. Methods A retrospective analysis was performed for the clinical data of children with PM caused by Escherichia coli (12 children) or Streptococcus pneumoniae (15 children). Results Compared with the Streptococcus pneumoniae infection group, the Escherichia coli infection group had a significantly higher proportion of children with an age of onset of <3 months and a significantly higher incidence rate of convulsion, but significantly lower incidence rates of severe fever (>39°C) and disturbance of consciousness and a significantly lower proportion of children with an increased leukocyte count at diagnosis (>12×109/L). The results of routine cerebrospinal fluid test and biochemical examinations showed no significant differences between the two groups. Escherichia coli and Streptococcus pneumoniae were resistant to cephalosporins and had a sensitivity to chloramphenicol more than 90%. Escherichia coli was fully sensitive to meropenem and Streptococcus pneumoniae was fully sensitive to vancomycin. Conclusions PM caused by Escherichia coli and Streptococcus pneumoniae has different clinical features. As for PM children with severe fever, disturbance of consciousness, and an increased leukocyte count, the probability of Streptococcus pneumoniae infection should be considered. For PM children with an age of onset of <3 months, medium- and low-grade fever, frequent convulsions, and a leukocyte count of <12×109/L, the probability of Escherichia coli infection should be considered.关键词
大肠杆菌/肺炎链球菌/化脓性脑膜炎/临床特点/儿童Key words
Escherichia coli/Streptococcus pneumoniae/Purulent meningitis/Clinical feature/Child引用本文复制引用
韩慰,蒋莉,马建南,宋晓洁,何蓉..大肠杆菌与肺炎链球菌所致儿童化脓性脑膜炎临床特点对比分析[J].中国当代儿科杂志,2016,18(7):573-576,4.
