中国动脉硬化杂志2016，Vol.24Issue(7)：737-741,5.
G蛋白偶联受体5在动脉粥样硬化发生发展中的作用
The Role of G Protein-coupled Receptor 5 in the Development of Atherosclerosis
摘要
Abstract
G protein-coupled receptor 5 (TGR5) is recently discovered to be a new membrane receptor that can regulate inflammation and metabolism.TGR5 activation can inhibit foam cell formation and atherosclerotic plaque rupture by reducing inflammation reaction,promote NO,H2S and other endogenous gas signal molecules to improve vascular endothelial dysfunction.In addition,it also can reduce atherosclerosis risk factors such as obesity and diabetes.Therefore,TGR5 may be an important target for prevention and treatment of atherosclerosis.关键词
G蛋白偶联受体5/动脉粥样硬化/炎症反应/血管内皮功能障碍Key words
G Protein-coupled Receptor 5/Atherosclerosis/Inflammation Reaction/Vascular Endothelial Dysfunction分类
医药卫生引用本文复制引用
文星,冯健,李家富..G蛋白偶联受体5在动脉粥样硬化发生发展中的作用[J].中国动脉硬化杂志,2016,24(7):737-741,5.基金项目
国家自然科学基金项目(31300946) （31300946）
泸州市人民政府-泸州医学院科技战略合作科技项目(2013LZLY-J22) （2013LZLY-J22）
