中国临床药理学与治疗学2016，Vol.21Issue(5)：509-513,5.
虾青素对Beagle犬心肌梗死模型的保护作用及其降低氧化应激机制
Protective effect of astaxanthin on experimental myocardial infarct in Beagle dogs and its mechanism on lowing oxidative stress
摘要
Abstract
AIM:To investigate the protective effect of astaxanthin (ASX) on Beagle dogs after myocardial infarction (MI) and its mechanism on lowing oxidative stress.METHODS:The Beagle dogs were dosed with astaxanthin [the ASX group,100 (mg · kg-1 · d-1) or distilled water (the sham-operated group and the MI group) for one week,The MI model was made by ligation of the left coronary artery,and continue to give ASX for three weeks.Electrocardiogram (ECG) and myocardial enzyme spectrum and antioxidant in serum were measured at different time during surgery.Western blot was used to examine the expression of nuclear factor erythroid 2-related factor-2 (Nrf2)at the infarcted border zone,and the pathomorphological changes of heart were observed.RESULTS:With ASX,the elevation of ECG ST segment in myocardial infarction dogs was significantly decreased,the serum level of the creatine kinase-MB (CK-MB) and troponin Ⅰ (cTnI) and malondialdehyde (MDA) was also reduced,while the activity of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) upregulated,the protein expression of Nrf2 at the infarcted border zone were increased.Also,the area of MI and the degree of myocardial cell necrosis in dogs were reduced.CONCLUSION:Astaxanthin plays a protective role in MI dogs,its mechanism is related to reduce oxidative stress.关键词
虾青素/心肌梗死/心脏保护作用/氧化应激Key words
astaxanthin/myocardial infarction/protective effect/oxidative stress分类
医药卫生引用本文复制引用
邓祖跃..虾青素对Beagle犬心肌梗死模型的保护作用及其降低氧化应激机制[J].中国临床药理学与治疗学,2016,21(5):509-513,5.基金项目
浙江省省级公益性技术应用研究计划项目(Y206355)资助 （Y206355）
