中国临床药理学与治疗学2016，Vol.21Issue(5)：526-532,7.
TCF7L2基因rs7903146多态性与2型糖尿病关系的Meta分析
The relationship between polymorphism of rs7903146 inTCF7L2 gene and 2-diabetes mellitus: a Meta-analysis
摘要
Abstract
AIM:To systematically review the relationship between polymorphism of rs7903146 inTCF7L2 gene and 2-diabetes mellitus.METHODS:Researches about rs7903146 inTCF7L2 gene were selected from Chinese National Knowledge Infrastructure,Chinese Wanfang Data Knowledge Service Platform,and Pubmed database.Software Stata 11.0 was applied to do Meta-analysis about these researches.RESULTS:Twenty five studies were eligible for inclusion in the Meta-analysis.There was 25 560 cases in this study which included 13 748 patients in group T2DM and 11 812 healthy people in Control group.Meta-analysis results showed that literature of gentype(TT + TC)/CC had higher heterogeneity (I2 =72.9％).After combining analysis by using random effect model,the OR value of genotype frequency of effectsize (TT + TC)/CC was 1.52,(95％ CI:1.34-1.71,P =0.000).Significant difference was detected among the population of Southeast Asia,Europe and America while was absent in West Asia.The results of Meta-analysis were stable without significant publication bias after sensitivity analysis and funnel plot of the Begg's test and Egger's test.The random effect model was used to analysis allelic gen of T/C for the higher heterogeneity (I2 =73.5％).The results were stable and pooled OR 1.43,(95％CI:1.30-1.57,P=0.000).No publication bias was found in this study.CONCLUSION:There is significant correlation between polymorphism of rs7903146 in TCF7L2 gene and 2-diabetes mellitus.The genotype of TT +CT is a risk factor of the incidence of T2DM.The allelic gen of T is alsoa risk factor of T2DM.关键词
TCF7L2基因/2型糖尿病/基因多态性/Meta分析Key words
TCF7L2/2 type diabetes mellitus/gen polymorphism/Meta-analysis分类
医药卫生引用本文复制引用
梁伟,朱丽君,段滢,金岳龙,贺连平,常微微,姚应水..TCF7L2基因rs7903146多态性与2型糖尿病关系的Meta分析[J].中国临床药理学与治疗学,2016,21(5):526-532,7.基金项目
国家自然科学基金资助项目(81441127) （81441127）
