中国临床药理学与治疗学2016，Vol.21Issue(5)：553-557,5.
阿魏酸钠治疗尘肺病肺纤维化的效果及其作用机制的临床研究
Clinical study on sodium ferulate for pneumoconiosis with pulmonary fibrosis
摘要
Abstract
AIM:To observe the effect and its mechanism of sodium ferulate for pulmonary fibrosis indexes such as Co I and PⅢP,on patients with pneumoconiosis.METHODS:70 pneumoconiosis patients were randomly divided into the treatment group and the control group,each with 35 patients.All patients were given conventional treatment with spray-inhalation of 4％ polyvinylpyridine-N-oxide,10 mL,30 min per time,6 times per week.An extra 6-month treatment of sodium ferulate tablets were given to the treatment group,2 tablets per time,3 times per day.Changes of clinical symptoms,blood gas analysis index,pulmonary fibrosis index,D-dimer,ET(endothelin) were monitored before and after treatment in the two groups.RESULTS:Clinical symptoms,blood gas analysis index and pulmonary fibrosis index of the two groups were significantly improved than those of before treatment (P ＜ 0.05).The clinical total effective rate,blood gas analysis index and pulmonary fibrosis indexes such as Co Ⅰ and PⅢP,D-dimer,ET in the treatment group were significantly improved compared with the control group (P ＜ 0.05).There was no significant difference in adverse reactions between the two groups (P ＞ 0.05).CONCLUSION:Sodium ferulate can effectively improve the pulmonary ventilation function and inhibit pulmonary fibrosis of patients with pneumoconiosis.To inhibit the synthesis of collagen by inhibiting the pathological effects of ET can be the possible underlying mechanism.关键词
阿魏酸钠/克矽平/尘肺病/肺纤维化Key words
sodium ferulate/polyvinylpyridine-N-oxide/pneumoconiosis/pulmonary fibrosis分类
医药卫生引用本文复制引用
韩静茵,贾仰民,王淑娟..阿魏酸钠治疗尘肺病肺纤维化的效果及其作用机制的临床研究[J].中国临床药理学与治疗学,2016,21(5):553-557,5.基金项目
浙江省中西医结合学会临床药学科研基金振德专项(2013LYZD006) （2013LYZD006）
