中国临床药理学杂志2016，Vol.32Issue(12)：1078-1080,1084,4.DOI:10.13699/j.cnki.1001-6821.2016.12.007
喹硫平联合丙戊酸镁治疗双相情感障碍的临床研究
Clinical trial of quetiapine combined with valproate in the treatment of bipolar disorder
摘要
Abstract
Objective To evaluate the clinical efficacy and safety of quetiapine combined with valproate in the treatment of bipolar disorder.Methods Ninety-four patients of bipolar disorder were randomly divi-ded into control group ( n=47 ) and treatment group ( n=47 ).Control group was given oral valproate 500 mg, qd, and according to the tole-rance of the patients increased the dose of 750 mg, qd after one week.Treatment group was based on the treatment of control group , and re-ceived oral quetiapine 100 mg, qd for starting dose , then increased the dosage 100 mg daily in day 1-4, to 600 mg in day 5-7, to 800 mg, qd in day 8-28.Two groups were treated for 28 d.The clinical efficacy , serum total bilirubin ( TBIL ) , albumin , levels of inflammatory factors , quality of living evaluation , Bech -Rafaelsen mania scale ( BRMS ) , Hamilton depression scare(HAMD) scores and the safety were compared between two groups.Results After treatment , there were no significant difference in clinical efficacy between two groups ( P >0.05 ).After treatment, the levels of TBIL and albumin were significantly higher than those of control group ( P <0.05 ) , the levels of interleukin -1βand interleukin-4 in treatment group were significantly lower than those in control group ( P <0.05 ).The BRMS and HAMD scores in treatment group were significantly lower than those in control group ( P <0.05 ) . There was no significant difference in the incidence of adverse drug reactions between two groups ( P >0.05 ).Conclusion Quetiapine combined with valproate have a definite clinical efficacy and safety in the treatment of bipolar disorder, which can significantly improve the quality of life and reduce the manic and depressive symptoms.关键词
喹硫平/丙戊酸镁/双相情感障碍/安全性Key words
quetiapine/valproate/bipolar disorder/safety分类
医药卫生引用本文复制引用
于浚玫,白凤凤..喹硫平联合丙戊酸镁治疗双相情感障碍的临床研究[J].中国临床药理学杂志,2016,32(12):1078-1080,1084,4.基金项目
国家“重大新药创制”科技重大专项基金资助项目 （）
