中国临床药理学杂志2016，Vol.32Issue(12)：1081-1084,4.DOI:10.13699/j.cnki.1001-6821.2016.12.008
神经节苷脂联合康复训练对脊髓损伤患者炎性因子及神经功能恢复的影响
Influence of ganglioside combined with rehabilitation training on inflammatory cytokines and neurological recovery in patients with spinal cord injury
摘要
Abstract
Objective To explore the influence of ganglioside combined with rehabilitation training on inflammatory cytokines and neurological recovery in patients with spinal cord injury ( SCI ).Methods Eighty-six patients with SCI were randomly divided into control group ( n=43 ) and treatment group ( n =43 ) .Control group was only received rehabilitation training.Treatment group was treated with ganglioside 20 mg, qd for 20 d, then discontinuation for 10 d, on the basis of control group.Two groups were treated for 2 cycles, each was 30 d.The levels of serum tumor necrosis factor alpha ( TNF -α) , interleukin -8 ( IL-8 ) and IL-1βwere determined by enzyme -linked immuno sor-bent assay ( ELISA) , the neurological recovery was evaluated by Ameri-can Spinal Injury Association ( ASIA).The clinical efficacy and the inci-dence of adverse drug reactions were compared between two groups.Results After treatment , the total effective rate in treatment group was higher than that in control group with significant difference ( 90.70% vs 72.09%, P<0.05 ).After treatment , the levels of TNF-α, IL-8 and IL-1βin treatment group were significantly lower than those in control group ( P <0.01 ).The ASIA scores of motion , pain and touch in treatment group were higher than those of control group ( P <0.01 ).There was no significant difference in the incidence of adverse drug reactions between two groups ( P >0.05 ).Conclusion Ganglioside combined with rehabilitation training has a definitive clinical efficacy for the treatment of SCI , which can reduce the expression of serum inflammatory factors and improve the neurological recovery , without increasing the incidence of adverse drug reactions.关键词
脊髓损伤/康复训练/神经节苷脂/炎性因子/神经功能恢复Key words
spinal cord injury/rehabilitation training/ganglioside/inflammatory cytokines/neurological recovery分类
医药卫生引用本文复制引用
吴猛,李雄锋,吴玮,李建有..神经节苷脂联合康复训练对脊髓损伤患者炎性因子及神经功能恢复的影响[J].中国临床药理学杂志,2016,32(12):1081-1084,4.基金项目
浙江省自然科学基金资助项目 （）
