中国临床药理学杂志2016，Vol.32Issue(12)：1085-1087,3.DOI:10.13699/j.cnki.1001-6821.2016.12.009
拉莫三嗪联合丙戊酸钠治疗难治性癫痫部分性发作的临床研究
Clinical trial of lamotrigine combined with sodium valproate in the treatment of intractable epilepsy partial seizure
摘要
Abstract
Objective To evaluate the clinical efficacy and safety of lamotrigine combined with sodium valproate in the treatment of intractable epilepsy partial seizure.Methods One hundred patients with intractable epilepsy partial seizure were randomly divided into control group ( n=50 ) and treatment group ( n=50 ).Control group was taken with sodium valproate 0.2 g · d -1 , qd.Treatment group was based on the treatment of control group, and plused with lamotrigine (1-2 weeks the dosage of 12.5 mg · d-1 , qd; and two weeks later , the dosage was adjusted to 25 mg· d-1 , qd;if there was no medication adjustment , the dosage increased to 100-200 mg · d -1 for maintenance therapy ).Two groups were required to continue medication to ensure the disease control.The clinical efficacy , frequency of attack , changes of epileptic discharges during onset period after treatment , and the incidence of adverse drug reactions were compared between two groups.Results After 3, 6 months of treatment , the total effective rate in treatment group were significantly higher than those in control group ( 82.00% vs 66.00%, 92.00%vs 76.00%, P <0.05 ).After 3, 6 months of treatment , the frequency of attack in treatment group was significantly lower than that in control group [ ( 7.64 ±1.28 ) vs (10.39 ±2.31), (1.98 ±0.52)vs(6.82 ±1.14), P<0.05].After 3, 6 months of treatment, the changes of epilep-tic discharges during onset period in treatment group were significantly lower than those in control group [ 78.00% vs 92.00%, 64.00%vs 82.00%, P<0.05].The difference of the incidence of adverse drug reactions was not statis-tically significant ( P>0.05 ).Conclusion Lamotrigine combined with sodium valproate has a definitive clinical efficacy for the treatment of intractable epilepsy partial seizure, which may reduce the frequency of attack and safety.关键词
拉莫三嗪/丙戊酸钠/难治性癫痫部分性发作/安全性Key words
lamotrigine/sodium valproate/intractable epilepsy partial seizures/safety分类
药学引用本文复制引用
张华..拉莫三嗪联合丙戊酸钠治疗难治性癫痫部分性发作的临床研究[J].中国临床药理学杂志,2016,32(12):1085-1087,3.基金项目
浙江省中医药科技计划基金资助项目 （）
