中国临床药理学杂志2016，Vol.32Issue(12)：1098-1100,3.DOI:10.13699/j.cnki.1001-6821.2016.12.013
拉坦前列素降眼压疗效与前列腺素受体基因多态性的相关性研究
Relationship of the efficacy of latanoprost in lowering intraocular pressure and the genetic polymorphism of prostaglandin receptor gene
摘要
Abstract
Objective To study the association between the efficacy of latanoprost in lowing intraocular pressure and genetic polymorphisms of prostaglandin receptor ( PTGFR ) gene.Methods A pharmacogenetic analysis was performed by using fluorescence in situ hybridization ( FISH) to analyze the genotype of single nucleotide polymorphism ( SNPs ) ( rs3766355 , rs3753380 ) in patients with ocular hypertension and primary open -angle glaucoma who were treated with latanoprost.Results Sixty -five partients completed follow -up.The CC +CA genotypes in rs3766355 may be of high response to latanoprost versus AA genotype in patients with ocular hypertension or primary open -angle glau-coma(P<0.05), but no significant difference was found among TT +TC versus CC genotype in rs3753380 ( P >0.05 ).Conclusion SNP of rs3766355 in PTGFR may be associated with the effect of latanoprost.关键词
拉坦前列素/前列腺素受体/基因多态性/青光眼Key words
latanoprost/prostaglandin receptor/gene polymorphism/glaucoma分类
医药卫生引用本文复制引用
宋尧,赵秀丽,马科..拉坦前列素降眼压疗效与前列腺素受体基因多态性的相关性研究[J].中国临床药理学杂志,2016,32(12):1098-1100,3.基金项目
国家十二五“重大新药创新”科技重大专项基金资助项目 （）
