中国临床药学杂志2016，Vol.25Issue(3)：141-144,4.
甲钴胺联合依帕司他治疗2型糖尿病周围神经病变的疗效
Effect of mecobalamine and epalrestat combination therapy on peripheral neuropathy in type 2 diabetic patients
蒋翠萍 1陈一 2冯强 1孙华 1顾芹1
作者信息
- 1. 复旦大学附属华东医院内分泌科,上海200040
- 2. 复旦大学附属华东医院康复科,上海200040
- 折叠
摘要
Abstract
AIM To explore the effect of mecobalamine and epalrestat combination therapy on peripheral neuropathy in type 2 diabetic paticnts.METHODS Ninty type 2 diabetic patients with peripheral neuropathy were enrolled in this study.All patients were selected according to the 1999 WHO diagnostic criteria for diabetes and the 2009 diagnostic criteria proposed by Chinese Medical Association of endocrine and metabolism for diabetic peripheral neuropathy(DPN).After blood glucose levels had reached the target,the patients were randomized to receive mecobalamine (M,n =30),or epalrestat (E,n =30),or mecobalamine and epalrestat combination therapy (M + E,n =30) for 12 weeks.At the end of the treatment,the neuropathy symptoms and nerve conduction velocity of each patient were valued through electromyography.RESULTS At the end of this study,the rates of those with significant improvement in neuropathy symptoms were 33.33％,39.28％ and 65.51％ respectively in group M,group E and combination group(M + E).And the effective rates in group M + E was significantly higher than those in the other 2 groups (P ＜ 0.05).The sensory nerve conduction velocity (SNCV) and the motor nerve conduction velocity (MNCV) of patients were significantly increased from baseline (P ＜ 0.01),especially in group M + E.CONCLUSION Mecobalamine and epalrestat combination therapy could be more effective in DPN treatment.关键词
糖尿病周围神经病变/甲钴胺/依帕司他Key words
diabetic peripheral neuropathy/mecobalamine/epalrestat引用本文复制引用
蒋翠萍,陈一,冯强,孙华,顾芹..甲钴胺联合依帕司他治疗2型糖尿病周围神经病变的疗效[J].中国临床药学杂志,2016,25(3):141-144,4.
