中国全科医学2016，Vol.19Issue(20)：2371-2374,4.DOI:10.3969/j.issn.1007-9572.2016.20.002
质子泵抑制剂与骨代谢关系的研究进展
Research Progress of Association Between Proton Pump Inhibitors and Bone Metabolism
摘要
Abstract
Proton pump inhibitors(PPI)are widely used to treat acid - related disorders,such as gastroesophageal reflux disease and peptic ulcer. Studies have reported that the long - term use of PPI may lead to increased risk of bone fracture. This article briefly reviews the advances in the research about the relationship between PPI and calcium absorption,bone mineral density and bone fractures. The mechanism by which long - term use of PPI induces bone fracture is also reviewed. Current evidences show that there is a certain association between PPI therapy and the risk of fracture,but the correlation is not strong;the potential mechanism is still not clear. Therefore,in the clinical practice,indications and the course of treatment of PPI treatment should be strictly controlled,and the long - term administration of PPI should be avoided,especially for patients with high risk for bone fracture.关键词
骨质疏松/骨折/质子泵抑制剂/骨代谢/综述Key words
Osteoporosis/Fractures,bone/Proton pump inhibitors/Bone metabolism/Review分类
医药卫生引用本文复制引用
张伟,刘彦,姜春燕..质子泵抑制剂与骨代谢关系的研究进展[J].中国全科医学,2016,19(20):2371-2374,4.基金项目
国家自然科学基金青年基金资助项目 （）
