Abstract
Objective Vitamin D is thought to play an important role in the pathogenesis and glycometabolism of type 2 diabetes patients. In the study,we observed the effect of small - dose and long - term supplement of α-calciferol supplement on the islet - β cell function,insulin resistance,glucolipid metabolism and anti - inflammatory action of type 2 diabetes patients. Methods From February 2011 to October 2013,we enrolled 92 T2DM patients who received treatment in the Geratic Hospital of Jiangsu Province. According to the principle of same gender,similar age and the course of disease,the patients were divided into treatment group and control group,with 46 patients in each group. The two groups both received orally - taken hypoglycemic agent;treatment group was orally given 0. 25 μg α-calciferol by one time per day,and control group was orally given 0. 25 μg placebo(dietary fiber)by one time per day. The intervention was given for 18 months continuously,and the double blind method was employed on the research subjects and research conductors. At baseline and after intervention for 3,6,12,18 months,fasting blood samples were taken,and the levels of vitamin D,C - peptide,fasting insulin,HbA1c ,VLDL-C, LDL-C,Lp(a),serum calcium,serum phosphate,hs-CRP and Hcy were detected. Results At baseline,no differences between the two groups were observed in BMI,vitamin D,C - peptide,HOMA-IR,HOMA-β cell function indexes,HbA1c , VLDL-C,LDL-C,Lp(a),serum calcium,serum phosphate,hs-CRP and Hcy levels(P > 0. 05). After intervention for 3 months,treatment group was lower in HOMA-IR than control group( P < 0. 05). After intervention for 6 months,treatment group was higher in C - peptide levels and HOMA-β cell function indexes and lower in HOMA-IR and hs-CRP levels than control group(P < 0. 05). After intervention for 12 months,treatment group was higher in C - peptide levels and HOMA-β cell function indexes and lower in HOMA-IR,HbA1c ,VLDL-C,LDL-C,hs-CRP and Hcy levels than control group(P < 0. 05). After intervention for 18 months,treatment group was higher in C - peptide level and HOMA-βcell function indexes and lower in HOMA-IR,HbA1c ,VLDL-C,LDL-C,hs-CRP and Hcy levels than control group( P < 0. 05). Conclusion Small - dose and long - term supplement of α-calciferol can faciliate the insulin secretion of T2DM patients,improve islet - β cell function, insulin resistance and glucolipid metabolism,and lower inflammatory factor level.关键词
糖尿病,2 型/骨化醇类/胰岛素抵抗/超敏 C 反应蛋白/同型半胱氨酸Key words
Diabetes, type 2/Ergocalciferols/Insulin resistance/Hyper - sensitive C - reactive protein/Homocysteine分类
医药卫生
