中国全科医学2016，Vol.19Issue(20)：2390-2394,5.DOI:10.3969/j.issn.1007-9572.2016.20.006
不同剂量川芎嗪辅助手术治疗老年人突发脑梗死的预后研究
Prognosis of Elderly Patients With Sudden Cerebral Infarction After Surgical Treatment Aided by Different Doses of Ligustrazine
摘要
Abstract
Objective To investigate the influence of different doses of ligustrazine used in surgical treatment on elderly patients with sudden cerebral infarction. Methods From June 2012 to December 2014,we selected 110 elderly patients with sudden cerebral infarction who received diagnosis and treatment in the Third Hospital of Chinese People′s Armed Police Forces. Random parallel control method was used to divide patients into control group and treatment group,with 55 patients in each group. All patients were given basic treatment and lumbar puncture or lumbar cistern drainage. Control group was given high- dose ligustrazine injection adjuvant therapy with intravenous drip of 160 mg of ligustrazine and 250 ml of 0. 9% sodium chloride injection,and the treatment group was given low - dose ligustrazine injection adjuvant therapy with 40 mg of ligustrazine and 250 ml of 0. 9% sodium chloride injection. Both groups received the therapies for 14 days. Efficacy and neurological function defect scale of the two groups were observed,and the levels of AngⅡ and LPA were determined. Adverse reactions during treatment were recorded. Results After treatment,the effective rates of treatment group and control group were 96. 4% (53 / 55)and 80. 0%(44 / 55),with treatment group higher than control group(χ2 = 6. 445,P < 0. 05). Before treatment,the two groups were not significantly different in the scores of neurological function defect scale(P > 0. 05);after treatment,treatment group was lower than control group in the scores of neurological function defect scale(P < 0. 05);the two groups had lower scores of neurological function defect scale after treatment than that before treatment ( P < 0. 05 ). Before treatment,the two groups were not significantly different in the levels of AngⅡ and LPA(P > 0. 05);after treatment,treatment group was lower than control group in the levels of AngⅡ and LPA(P < 0. 05);the two groups had lower levels of AngⅡ and LPA than those before treatment(P< 0. 05 ). The patients did not have adverse reactions of bleeding,fever,rash and liver and kidney function damage. Conclusion Compared with higher dose of ligustrazine,lower dose of ligustrazine used in the surgical treatment on elderly patients with sudden cerebral infarction can effectively improve neurological function and therapeutic effect and has safety. Its effect may be related with the down - regulation of AngⅡ and LPA levels.关键词
脑梗死/药物剂量/川芎嗪/老年人/血管紧张素Ⅱ/溶血磷脂酸类Key words
Drug dosage/Ligustrazine/Aged/Brain infarction/Angiotensin Ⅱ/Lysophospholipids分类
医药卫生引用本文复制引用
呼建民,王述莲,刘献增..不同剂量川芎嗪辅助手术治疗老年人突发脑梗死的预后研究[J].中国全科医学,2016,19(20):2390-2394,5.基金项目
北京大学人民医院研究与发展基金资助项目 （）
