中国全科医学2016，Vol.19Issue(20)：2406-2409,4.DOI:10.3969/j.issn.1007-9572.2016.20.009
前列腺特异性抗原密度预测前列腺癌包膜侵犯的价值研究
Prediction Value of Prostate-specific Antigen Density in Capsular Invasion of Prostate Cancer
摘要
Abstract
Objective To discuss the predictive value of prostate - specific antigen density( PSAD)in capsular invasion of prostate cancer. Methods 222 patients with localized prostate cancer,who were treated in the Department of Urology of the First Affiliated Hospital of Zhejiang University from March 2007 to January 2014,were selected as the study subjects. According to their postoperative pathological stages,we divided the patients into capsular invasion group(stage pT3a ,n= 110)and localized in - capsule group(stage pT2 ,n = 112). The differentiation degree of prostate cancer was assessed by adopting Gleason score. After the collection of the peripheral venous blood,we detected the total prostate - specific antigen (tPSA)and the free prostate - specific antigen( fPSA),and calculated the ratio of the two( f/ t). The prostate volume was measured by transrectal B ultrasonography to calculate PSAD. Results There was no significant difference in age between the two groups(P > 0. 05). There were significant differences in Gleason score,tPSA,f/ t and PSAD( P < 0. 05). The areas under the ROC curve(AUC)of Gleason score,tPSA,f/ t,PSAD in predicting the capsular invasion of patients with prostate cancer were 0. 623〔95% CI(0. 549,0. 697)〕,0. 653〔95% CI(0. 582,0. 725)〕,0. 338〔95% CI(0. 267,0. 408)〕and 0. 708〔95% CI(0. 641,0. 775)〕respectively,showing significant differences( P < 0. 05). The best critical point of PSAD was 0. 27 ng·ml - 1 ·cm - 3 with a sensitivity and specificity degree of 83. 6% and 48. 2% respectively,and the positive and negative predictive value were 47. 0% and 84. 2% respectively. The multivariate Logistic regression analysis showed that high PSAD was the risk factor of capsular invasion of prostate cancer〔 OR = 4. 639,95% CI(1. 303,16. 514),P = 0. 018〕. Conclusion There is certain accuracy of PSAD in predicting capsular invasion of prostate cancer,which has certain clinical application value.关键词
前列腺肿瘤/前列腺特异性抗原/前列腺特异性抗原密度/包膜侵犯Key words
Prostatic neoplasms/Prostate - specific antigen/Prostate - specific antigen density/Capsular invasion分类
医药卫生引用本文复制引用
翁锡君,谢立平,郑祥义,汪朔,蔡柏森,项尖尖,尤启汉..前列腺特异性抗原密度预测前列腺癌包膜侵犯的价值研究[J].中国全科医学,2016,19(20):2406-2409,4.基金项目
国家临床重点专科建设项目（2012泌尿外科）；浙江省中西医结合前列腺病学重点学科 （）
