Abstract
Objective To analyze the correlation of anti - cross reactive carbohydrate determinants IgE(anti-CCDIgE level)with serum IgE level and skin prick test(SPT)of patients with allergic rhinitis. Methods From January 2012 to July 2013,we enrolled 161 patients who were definitely diagnosed as allergic rhinitis or non - allergic rhinitis and accorded with inclusion criteria in Peking University First Hospital. According to whether the patients had non - allergic rhinitis,they were divided into allergic rhinitis group(n = 121)and control group(n = 40). General data of patients were collected,including gender,age and history of hymenoptera stings. Dot immunobloting( dot-IBT)was used to detect the expression of sIgE and anti-CCDIgE. Phadiatop and tIgE expression was detected by FEIA,and SPT was conducted. The correlation of anti-CCDIgE expression with gender,age,history of hymenoptera stings,and the expression of sIgE,phadiatop,tIgE and SPT sensitization was analyzed,and the correlation of SPT results with gender,age,and the experession of phadiatop and tIgE was also analyzed. Results Allergic rhinitis group was higher than control group in the positive expression rate of sIgE,anti-CCDIgE,phadiatop and tIgE and SPT positive rate(P ﹤ 0. 05). The expression of anti - CCDIgE had no correlation with gender,age,expression of mixed trees,humulus,mugwort,household dust,mixed dust mites,mixed fungus,cockroaches,dog dander and cat dander of sIgE atopic allergens,expresion of phadiatop,expresion of trees 1,weeds,spruce,humulus,trees 2,gramineae/ grain, mugwort,robinia pseudoacacia, pine, dust mites, household dust mites, aspergillus fumigatus, candida albicans, cockroaches,gramineae,mould 1,mould 2 and animal dander of SPT inhaled allergens(P ﹥ 0. 05);the expression of anti -CCDIgE had correlation with history of hymenoptera stings,ragweed of sIgE atopic allergens,tIgE expression,quinoa and goosefoots of SPT inhaled allergens(P ﹤ 0. 05). SPT results had no correlation with gender and tIgE expression(P ﹥ 0. 05), and had correlation with age and phadiatop expression(P ﹤ 0. 05). SPT positive rate increased as age increased(χ2trend = 4. 264, P = 0. 039). Conclusion The anti-CCDIgE expression of patients with allergic rhinitis has correlation with serum IgE( sIgE and tIgE)level and SPT result. The expression of anti-CCDIgE disturbs the SPT and sIgE for the diagnosis of allergens.关键词
鼻炎,变应性/抗交叉反应性糖类决定簇 IgE/免疫球蛋白 E/皮肤点刺试验Key words
Rhinitis,allergic/Anti-CCDIgE/Immunoglobulin E/Skin prick test分类
医药卫生
