中国全科医学2016，Vol.19Issue(21)：2509-2512,2521,5.DOI:10.3969/j.issn.1007-9572.2016.21.004
胃癌组织中 Vav3表达与肿瘤侵袭转移的关系及临床意义研究
Relation Betw Relation Betw een Vav3 Expression and Tumor Invasion and Metastasis in Gastric Cancer Tissue and the Clinical Significance
摘要
Abstract
Objective To investigate the relation between Vav3 expression and tumor invasion and metastasis in gastric cancer tissue and the clinical significance. Methods We collected the paraffin specimens of gastric cancer tissue and carcinoma side normal tissue from 92 patients who received resection for gastric carcinoma in the Third Surgery Department of the Fourth Affiliated Hospital of Hebei Medical University from May 2014 to May 2015. The expressions of Vav3,RelA,PCNA and MMP-2 in gastric cancer tissue and carcinoma side normal tissue were detected by immunohistochemistry staining. The relation between Vav3 expression and clinical and pathological characteristics in gastric cancer tissue was analyzed. The relation among Vav3, RelA,PCNA and MMP-2 expression was investigated by Spearman correlation analysis. Results The positive expression rate of Vav3 in gastric cancer tissue was 78. 3% (72 / 92),higher than 40. 2% (37 / 92)in carcinoma side normal tissue( χ2 = 27. 572,P ﹤ 0. 001). The positive expression rate of RelA in gastric cancer tissue was 88. 0% (81 / 92),higher than 52. 2% (48 / 92)in carcinoma side normal tissue(χ2 = 28. 242,P ﹤ 0. 001). The positive expression rate of PCNA in gastric cancer tissue was 73. 9% (68 / 92),higher than 47. 8% (44 / 92)in carcinoma side normal tissue(χ2 = 13. 143,P ﹤ 0. 001) . The positive expression rate of MMP-2 in gastric cancer tissue was 69. 6% ( 64 / 92 ),higher than 48. 9% ( 45 / 92 )in carcinoma side normal tissue( χ2 = 8. 125,P = 0. 004 ) . There was no significant difference in gender,age,depth of infiltration,and distant metastasis between high expression of Vav3 and low expression of Vav3 ( P ﹥ 0. 05 ) . There was significant difference in tumor differentiation degree,tumor diameter and the extent of lymph node metastasis between high expression of Vav3 and low expression of Vav3(P ﹤ 0. 05). The expression of Vav3 had positive correlation with the expression of RelA,PCNA and MMP-2(rs = 0. 338,P ﹤ 0. 001;rs = 0. 225,P = 0. 031;rs = 0. 267,P = 0. 010). The expression of RelA had positive correlation with the expression of PCNA( rs = 0. 336,P = 0. 001);the expression of RelA had no linear correlation with the expression of MMP-2(rs = 0. 176,P = 0. 094). The expression of PCNA had no linear correlation with the expression of MMP-2(rs = 0. 188,P = 0. 072). Conclusion There is overexpression of Vav3 in gastric cancer tissue,and the increase of Vav3 is associated with tumor metastasis and progress. Vav3 is involved in the progress and metastasis of gastric cancer by regulating RelA,PCNA and MMP-2 expression.关键词
胃肿瘤/肿瘤浸润/肿瘤转移/Vav3 蛋白Key words
Stomach neoplasms/Neoplasm invasiveness/Neoplasm metastasis/Vav3 protein分类
医药卫生引用本文复制引用
温转,王晓,檀碧波,李勇,刘庆伟,贾楠..胃癌组织中 Vav3表达与肿瘤侵袭转移的关系及临床意义研究[J].中国全科医学,2016,19(21):2509-2512,2521,5.基金项目
国家自然科学基金资助项目（81072033，81372580）；河北省科技支撑项目（14277779D）；河北省卫计委医学科学研究重点课题 （）
