中国实用妇科与产科杂志2016，Vol.32Issue(6)：583-587,5.DOI:10.7504/fk2016050124
人类白细胞抗原分型在淋巴细胞主动免疫治疗不明原因复发性流产中的价值研究
Clinical efficacy study of human leukocyte antigen typing in women of unexplained recurrent spontaneous abortion with lymphocyte immunotherapy
张莹 1乔福元 1曾万江 1刘海意 1徐鹏 1吴媛媛1
作者信息
- 1. 华中科技大学同济医学院附属同济医院妇产科,湖北武汉430000
- 折叠
摘要
Abstract
Objective Objective To investigate the role of human leukocyte antigen (HLA-DR/DQ) typing in women of URSA with lymphocyte immunotherapy.Methods We chose 243 patients that were diagnosed as URSA in Wuhan Tongji Hospital from May 2013 to March 2015 with negative blocking antibodies (BA).They were randomly assigned to two groups according to whether the patients and their blood donors were detected HLA-DR/DQ type before therapy,the observed group A was for less than one compatible site,and observed group B was for two compatible site.Compared the positive rate of BA and the successful pregnancy rate of two groups after therapy,and the Logistic regression was used for the analysis of related factors.Results The positive rate of BA and successful pregnancy rate in the observed group A was significantly higher than control group and observed group B,and the positive rate of BA and successful pregnancy rate in control group was significantly higher than observed group B,all the differences were statistically significant (P ＜ 0.05).The difference was not statistically significant after therapy when there was 0 or 1 HLA compatible site between the patients and their blood donors in observed group A (P ＞ 0.05).The rate of successful pregnancy rate in all of the observational group was significantly higher than the control group when the patients were younger than 35 years old and the difference was statistically significant (P ＜ 0.05).The difference was not statistically significant after treatment when the blood donor was their spouses or the third people (P ＞ 0.05).The Logistic regression analysis showed that age was an independent influencing factor of the positive rate of BA and successful pregnancy after lymphocyte immunotherapy.Conclusion The positive rate of BA and the successful pregnancy rate of URSA patients with HLA-DR/DQ were improved by HLA-DR/DQ typing before Lymphocyte immunotherapy.关键词
不明原因复发性流产/人类白细胞抗原/淋巴细胞主动免疫治疗/封闭抗体Key words
unexplained recurrent spontaneous abortion/HLA/lymphocyte immunotherapy/blocking antibody分类
医药卫生引用本文复制引用
张莹,乔福元,曾万江,刘海意,徐鹏,吴媛媛..人类白细胞抗原分型在淋巴细胞主动免疫治疗不明原因复发性流产中的价值研究[J].中国实用妇科与产科杂志,2016,32(6):583-587,5.
