中国药房2016，Vol.27Issue(19)：2678-2680,2681,4.DOI:10.6039/j.issn.1001-0408.2016.19.27
多指标综合评分法结合正交试验优化心力康颗粒中红参与丹参的混合醇提工艺Δ
Optimization of Ethanol Mixed-extraction Technology of Red ginseng and Salvia miltiorrhiza in Xinlikang Granules by Multiple Indexes Comprehensive Evaluation Method Combined with Orthogonal Test
摘要
Abstract
OBJECTIVE:To optimize the ethanol mixed-extraction technology of Red ginseng and Salvia miltiorrhiza in Xin-likang granules. METHODS:L9(34)orthogonal test was adopted to optimize ethanol mixed-extraction technology with ethanol vol-ume fraction,amount of ethanol and extraction times as factors using weighting coefficient comprehensive score of the contents of ginsenoside Rg1,Re and Rb1 in R. ginseng and the contents of tanshinone ⅡA and salvianolic acid B in S. miltiorrhiza as index;and the verification test was detected. RESULTS:Optimal mixed-ethanol extraction technology was as follows as 6-fold 70% etha-nol,reflux extracting for 3 times,2 h each time. In verification test,average contents of ginsenosides Rg1,Re,Rb1 in R. ginseng and those of tanshinone ⅡA and salvianolic acid B in S. miltiorrhiza were 3.963 8,0.757 3,4.986 2,0.964 7,27.662 5 mg/g,re-spectively,and comprehensive score was 0.96 (RSD=1.26%,n=3). CONCLUSIONS:Ethanol extraction technology of R. gin-seng and S. miltiorrhiza in Xinlikang granules optimized by multiple indexes comprehensive score combined with orthogonal test is stable,reasonable and feasible.关键词
心力康颗粒/红参/丹参/人参皂苷/丹参酮ⅡA/丹酚酸B/多指标综合评分/正交试验Key words
Xinlikang granules/Red ginseng/Salvia miltiorrhiza/Ginsenoside/Tanshinone ⅡA/Salvianolic acid B/Multiple indexes comprehensive evaluation/Orthogonal test分类
医药卫生引用本文复制引用
王少辰,郭宇洁,任烨,吴红金,刘建勋..多指标综合评分法结合正交试验优化心力康颗粒中红参与丹参的混合醇提工艺Δ[J].中国药房,2016,27(19):2678-2680,2681,4.基金项目
国家重点基础研究发展计划（973计划）（No.2015-CB554405）；北京中医药重点学科项目；首都医学发展科研基金--北京医学卫生科技重点支持项目（No.02Ⅱ02）；中国中医科学院科技创新团队 （）
