摘要
Abstract
Objective To explore the influence of midazolam on sedation depth and security in total intravenous anesthesia of radical operation of thyroid cancer. Method 84 patients who underwent radical operation of thyroid cancer in our hospital from September 2014 to September 2015 were randomly divided into group A and group B. Patients in group A were given midazolam before propofol during anesthesia induction and injected with flumazenil when the operation was finished. Patients in group B were given propofol, sufentanil and atracurium in order by intravenous fluids during anesthesia induction. After the success of tracheal intubation, pumped propofol, remifentanil and atracurium into vein to maintain reasonable levels of anesthesia. Compared the perioperative bispectral index (BIS), anesthesia recovery time and preoperative cognitive function between the two groups. Result There were no significant differences on BIS before anesthesia induction, 1 minute after anesthesia induction, 2 hours after anesthesia induction and when waking up between the two groups (P > 0.05). And at the time of 3 minutes after anesthesia induction, immediately after tracheal intubation and 1 hour after anesthesia induction, the BIS in group A were significant less than group B (P < 0.01); there was no significant difference in spontaneous breathing recovery time between the two groups (P > 0.05); group A had less time in opening eyes on verbal command and extubation than group B (P < 0.01). There were no significant differences in MMSE scores at 24 hours before operation,3 days and 7 days after operation between the two groups (P > 0.05); 24 hours after operation, the MMSE scores of group A was remarkably less than group B (P < 0.01). Conclusion There is intraoperative awareness risk in total intravenous anesthesia of radical operation of thyroid cancer. Using midazolam during anesthesia induction is helpful to improve the maintenance time of good anesthesia depth and to reduce the risk of intraoperative awareness, enhancing controllability of anesthesia with security.关键词
咪达唑仑/术中知晓/全凭静脉麻醉/脑电双频指数Key words
Midazolam/Intraoperative awareness/Total intravenous anesthesia/Bispectral index
