中国医学装备2016，Vol.13Issue(7)：70-73,4.DOI:10.3969/J.ISSN.1672-8270.2016.07.022
射波刀与伽玛刀治疗局部晚期胰腺癌的比较
Comparison of the efficacy of CyberKnife therapy with Gamma-Knife therapy in patients ;with locally advanced pancreatic cancer
张新红 1康静波 1朱奇 1徐云科 1张嘉月 1展晓宇 1李建国1
作者信息
- 1. 海军总医院肿瘤诊疗中心 北京 100048
- 折叠
摘要
Abstract
radiation therapy (Gamma-Knife) in treatment of locally advanced pancreatic cancer. Methods: 113 patients with locally advanced pancreatic cancer were divided into two groups according to receiving therapy method (CyberKnife group and Gamma-Knife group). Therapeutic effects, side effects, progression-free survival (PFS) and overall survival (OS) were recorded. Results: In the group of CyberKnife and Gamma-Knife, the objective response rate (ORR, CR+PR) was 75.56%and 73.53%(P>0.05), and the rate of pain alleviation was 94.74%and 94.52%(P>0.05), respectively. The median time of pain relief was 4 days and 16 days (P<0.01). After treatment, the index of total bilirubin and CA19-9 were significantly improved in both of the two groups, but there was no significant difference between them. The median time of follow-up was 28 months. The median PFS and OS in CyberKnife group and Gamma-Knife group were 10.1 and 8.7 months (t=10.07, P<0.05), 15.5 and 14.8 months, respectively (t=2.76, P>0.05). The rate of gastrointestinal tract side effect and myelosuppression in the two groups were 48.89%and 58.82%, 11.11%and 11.76%, respectively (x2=5.66, P>0.05). There was no grade 3-4 serious adverse reaction. Conclusion:Compared with Gamma-Knife therapy, CyberKnife therapy is more effective and safer for patients with advanced pancreatic cancer which can obtain similar local control rate and effective rate. But it can improve the PFS and has the characteristics of short course, fast effect and less adverse reaction.关键词
胰腺肿瘤/射波刀/立体定向放射治疗/体部伽玛刀Key words
Pancreatic cancer/CyberKnife/Stereotactic body radiation therapy/Gamma-Knife分类
医药卫生引用本文复制引用
张新红,康静波,朱奇,徐云科,张嘉月,展晓宇,李建国..射波刀与伽玛刀治疗局部晚期胰腺癌的比较[J].中国医学装备,2016,13(7):70-73,4.
